Patent classifications
C07D233/56
RING-FUSED THIAZOLINO 2-PYRIDONES, METHODS FOR PREPARATION THEREOF AND THEIR USE IN THE TREATMENT AND/OR PREVENTION OF A DISEASE INVOLVING GRAM-POSITIVE BACTERIA
The present disclosure provides a compound of Formula I, or a pharmaceutically acceptable salt thereof.
##STR00001##
NOVEL BORATE COMPOUND-CONTAINING COMPOSITION
A borate compound-containing composition soluble in hydrocarbon solvents. A composition containing base A, or a compound having a total carbon number of not less than 8 and represented by the formula (5):
##STR00001##
wherein R and R′ are each independently an optionally substituted C.sub.1-30 alkyl group, an optionally substituted C.sub.3-15 cycloalkyl group, or an optionally substituted C.sub.6-14 aryl group; and
a borate compound represented by the following formula (1):
##STR00002##
wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently a C.sub.6-14 aryl group substituted by one or more fluorine atoms or fluoro C.sub.1-4 alkyl groups; and
[A-H].sup.+ is a base A-derived cation. A method for producing a polymer, by polymerizing at least one kind of monomer selected from the group consisting of olefins and dienes by using the composition A as a cocatalyst.
Sulfonyldiazoles and N-(fluorosulfonyl)azoles, and methods of making the same
The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof, and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azolate salt, an N-silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azolate salts, or N-silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, an N-silylazole, or a combination thereof in one pot.
TETRACYCLINE COMPOUNDS AND METHODS OF TREATMENT
The present invention is directed to methods of treating hematological cancers, such as acute myleiod leukemia, with tetracyclines, or a pharmaceutically acceptable salt thereof.
Compounds which are inhibitors of Notum
A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I) ##STR00001##
Compounds which are inhibitors of Notum
A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I) ##STR00001##
COMPOSITION AND METHOD FOR TREATING DERMATOLOGICAL DISORDERS USING RETINAMIDES
Novel retinamides with unique properties and biological activities, including inhibition of retinoic acid metabolism and modulation of Mnk1/2-eIF4E and androgen receptor (AR) signaling pathways, are synthesized and developed. The novel retinamides are capable of effecting treatment of a variety of dermatological conditions while limiting adverse side effects.
COMPOSITION AND METHOD FOR TREATING DERMATOLOGICAL DISORDERS USING RETINAMIDES
Novel retinamides with unique properties and biological activities, including inhibition of retinoic acid metabolism and modulation of Mnk1/2-eIF4E and androgen receptor (AR) signaling pathways, are synthesized and developed. The novel retinamides are capable of effecting treatment of a variety of dermatological conditions while limiting adverse side effects.
Actinic ray-sensitive or radiation-sensitive resin composition, resist film, pattern forming method, and method for manufacturing electronic device
An actinic ray-sensitive or radiation-sensitive resin composition contains a compound that generates an acid upon irradiation with actinic rays or radiation and a resin whose polarity increases by the action of an acid, in which the compound is represented by a specific General Formula (X).
ONIUM SALT OF NITROGEN-CONTAINING HETEROARYL COMPOUND AND PEST CONTROL AGENT
A compound represented by formula (I) or formula (II) has a pest control effect. (In the formulae, Q.sup.1 represents a pyrazine ring or the like; G.sup.1 represents a nitrogen atom or a carbon atom; X.sup.1 represents an alkyl group or the like; m represents the number of X.sup.1 moieties; A represents an oxygen atom or the like; Y represents a single bond or the like; Q.sup.2 represents a benzene ring or the like; X.sup.2 represents an alkyl group, an aryl group or the like; X.sup.3 represents a halogeno group or the like; n represents the number of X.sup.3 moieties; Z.sup.q- represents a counter ion; and q represents 1 or 2.)
##STR00001##