Patent classifications
C07D237/02
IL-6 inhibitors and methods of treatment
The instant invention describes compounds having IL-6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by IL-6.
BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE
The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are believed useful for the treatment and/or prophylaxis of conditions that involve the Na.sup.+K.sup.+Cl.sup.− co-transporter or GABA.sub.A receptor.
BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE
The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are believed useful for the treatment and/or prophylaxis of conditions that involve the Na.sup.+K.sup.+Cl.sup.− co-transporter or GABA.sub.A receptor.
5-METHYL-6-PHENYL-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVE
The present invention provides an agent for treating malignant tumor, comprising a compound of formula (1):
##STR00001## wherein R.sup.1 to R.sup.4 are hydrogen atom, halogen, or etc., Y is optionally-substituted alkylene group or etc.
5-METHYL-6-PHENYL-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVE
The present invention provides an agent for treating malignant tumor, comprising a compound of formula (1):
##STR00001## wherein R.sup.1 to R.sup.4 are hydrogen atom, halogen, or etc., Y is optionally-substituted alkylene group or etc.
BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE
The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are believed useful for the treatment and/or prophylaxis of conditions that involve the Na.sup.+K.sup.+Cl.sup. co-transporter or GABA.sub.A receptor.
BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE
The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are believed useful for the treatment and/or prophylaxis of conditions that involve the Na.sup.+K.sup.+Cl.sup. co-transporter or GABA.sub.A receptor.
5-METHYL-6-PHENYL-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVE
The present invention provides an agent for treating malignant tumor, comprising a compound of formula (1):
##STR00001##
wherein R.sup.1 to R.sup.4 are hydrogen atom, halogen, or etc., Y is optionally-substituted alkylene group or etc.
5-METHYL-6-PHENYL-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVE
The present invention provides an agent for treating malignant tumor, comprising a compound of formula (1):
##STR00001##
wherein R.sup.1 to R.sup.4 are hydrogen atom, halogen, or etc., Y is optionally-substituted alkylene group or etc.
5-methyl-6-phenyl-4,5-dihydro-2H-pyridazin-3-one derivative
The present invention provides an agent for treating malignant tumor, comprising a compound of formula (1): ##STR00001## wherein R.sup.1 to R.sup.4 are hydrogen atom, halogen, or etc., Y is optionally-substituted alkylene group or etc.