Patent classifications
C
CHEMISTRY; METALLURGY
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C07
ORGANIC CHEMISTRY
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C07D
HETEROCYCLIC COMPOUNDS
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241/00
Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
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C07D241/02
not condensed with other rings
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C07D241/10
having three double bonds between ring members or between ring members and non-ring members
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C07D241/14
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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C07D241/24
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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C07D241/26
with nitrogen atoms directly attached to ring carbon atoms
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C07D241/28
in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
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C07D241/30
in which said hetero-bound carbon atoms are part of a substructure —C(=X)—X—C(=X)—X— in which X is an oxygen or sulphur atom or an imino radical, e.g. imidoylguanidines
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C07D241/32
(Amino-pyrazinoyl) guanidines
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C07D241/32

COMPOUNDS AND USES THEREOF
20230002356 · 2023-01-05 · ·

Provided herein are compounds, such as compounds for use in treating cancer. Also provided are methods of treating cancer, including treatment resistant cancer or cancer associated with a hypoxic tumor.

COMPOUNDS AND USES THEREOF
20230002356 · 2023-01-05 · ·

Provided herein are compounds, such as compounds for use in treating cancer. Also provided are methods of treating cancer, including treatment resistant cancer or cancer associated with a hypoxic tumor.

PURIFICATION OF SUBSTITUTED DIAMINOPYRAZINE DICARBOXYLIC ACIDS
20220315538 · 2022-10-06 ·

The present invention provides methods for the purification of the compound of Formula (I) from the precipitated reaction product comprising the compound of Formula (I), impurities, and/or residual or entrained solvents.

PURIFICATION OF SUBSTITUTED DIAMINOPYRAZINE DICARBOXYLIC ACIDS
20220315538 · 2022-10-06 ·

The present invention provides methods for the purification of the compound of Formula (I) from the precipitated reaction product comprising the compound of Formula (I), impurities, and/or residual or entrained solvents.

SODIUM CHANNEL BLOCKERS
20170267650 · 2017-09-21 · ·

The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

SODIUM CHANNEL BLOCKERS
20170267650 · 2017-09-21 · ·

The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
10526292 · 2020-01-07 · ·

Sodium channel blockers represented by the formula: ##STR00001##
are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.

Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
10526292 · 2020-01-07 · ·

Sodium channel blockers represented by the formula: ##STR00001##
are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.

3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS
20190308943 · 2019-10-10 · ·

The present invention relates compounds of the formula:

##STR00001##

or pharmaceutically acceptable salts thereof, useful as sodium channel blockers, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma, bronchiectasis, acute and chronic bronchitis, emphysema, and pneumonia.

SODIUM CHANNEL BLOCKERS
20190241528 · 2019-08-08 · ·

The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.