Provided is a novel process for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative. More specifically, provided is a process for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative represented by formula (1): ##STR00001## the process comprising reacting 3-aminopropan-1-ol with glyoxylic acid.

Provided is a novel process for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative. More specifically, provided is a process for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative represented by formula (1): ##STR00001## the process comprising reacting 3-aminopropan-1-ol with glyoxylic acid.

In a production method for a hemiaminal compound, a compound represented by Formula (1), a compound represented by Formula (2), and an oxidizing agent are mixed. A hemiaminal compound represented by Formula (3) is obtained. In a production method for a heterocyclic compound, a hemiaminal compound is mixed with a base.

##STR00001##

In a production method for a hemiaminal compound, a compound represented by Formula (1), a compound represented by Formula (2), and an oxidizing agent are mixed. A hemiaminal compound represented by Formula (3) is obtained. In a production method for a heterocyclic compound, a hemiaminal compound is mixed with a base.

##STR00001##

Provided is a novel process for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative.

More specifically, provided is a process for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative represented by formula (1):

##STR00001## the process comprising reacting 3-aminopropan-1-ol with glyoxylic acid.

Provided is a novel process for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative.

More specifically, provided is a process for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative represented by formula (1):

##STR00001## the process comprising reacting 3-aminopropan-1-ol with glyoxylic acid.

Disclosed are a method for preparing a carboxyl cyclic acid anhydride and a prepared product thereof. The disclosed method includes the steps of reacting a compound of formula (I) with a cyclization reagent to produce the compound of formula (II) and an acid, and using an epoxy compound as an acid scavenger. The disclosed method is low in cost, and has low requirements for reagents, places and equipment required for experiments, mild conditions, a wide application range of substrates and a high tolerance of functional groups. The synthesis route can recycle some solvents and other high value-added by-products, with less waste liquid discharge and easy amplification. It also has extremely high industrial and academic value, and can greatly promote the rapid mass production and application of products such as polyamino acid, polyhydroxy acid (polyester), and polymercaptic acid (polysulfide).

##STR00001##

Disclosed are a method for preparing a carboxyl cyclic acid anhydride and a prepared product thereof. The disclosed method includes the steps of reacting a compound of formula (I) with a cyclization reagent to produce the compound of formula (II) and an acid, and using an epoxy compound as an acid scavenger. The disclosed method is low in cost, and has low requirements for reagents, places and equipment required for experiments, mild conditions, a wide application range of substrates and a high tolerance of functional groups. The synthesis route can recycle some solvents and other high value-added by-products, with less waste liquid discharge and easy amplification. It also has extremely high industrial and academic value, and can greatly promote the rapid mass production and application of products such as polyamino acid, polyhydroxy acid (polyester), and polymercaptic acid (polysulfide).

##STR00001##

The present invention relates to a method for the production of d-erythro-sphingosine and analogs thereof, wherein the method comprises a step of condensing a compound of formula (2):

##STR00001## or a salt thereof,
wherein R.sup.1 is hydrogen, a C.sub.1-50 alkyl, preferably a C.sub.1-15 alkyl, more preferably a C.sub.10-15 alkyl, which may be saturated or contain one or more double and/or triple bonds, and/or which may contain one or more functional groups, the functional group being preferably selected from the group consisting of an alkoxy group, a secondary, or tertiary amine, a thioether, an acyloxy group, an acylamido group, a phosphorus containing functional group, a carboxyl group, or a carbonyl group, with a compound of formula (3):

##STR00002##

wherein the bond represents a double or a single bond, W is C, or C(OR.sup.4), Z is O, or OR.sup.5, provided that: when W is C, the bond is a double bond and Z is O, or when W is C(OR.sup.4), the bond is a single bond and Z is OR.sup.5, and
wherein R.sup.2 and R.sup.3 are independently selected from a saturated or unsaturated C.sub.1-6 alkyl, a saturated or unsaturated cycloalkyl, or an aryl, each of which may be substituted or unsubstituted, or wherein one of R.sup.2 and R.sup.3 is hydrogen, and the other rest is a saturated or unsaturated C.sub.1-6 alkyl, a saturated or unsaturated cycloalkyl, or an aryl, each of which may be substituted or unsubstituted, or wherein R.sup.2 and R.sup.3 may form a cyclic structure, R.sup.4 and R.sup.5 are independently selected from a C.sub.1-6 alkyl, a cycloalkyl, or an aryl, each of which may be substituted or unsubstituted.

The present invention relates to a method for the production of d-erythro-sphingosine and analogs thereof, wherein the method comprises a step of condensing a compound of formula (2):

##STR00001## or a salt thereof,
wherein R.sup.1 is hydrogen, a C.sub.1-50 alkyl, preferably a C.sub.1-15 alkyl, more preferably a C.sub.10-15 alkyl, which may be saturated or contain one or more double and/or triple bonds, and/or which may contain one or more functional groups, the functional group being preferably selected from the group consisting of an alkoxy group, a secondary, or tertiary amine, a thioether, an acyloxy group, an acylamido group, a phosphorus containing functional group, a carboxyl group, or a carbonyl group, with a compound of formula (3):

##STR00002##

wherein the bond represents a double or a single bond, W is C, or C(OR.sup.4), Z is O, or OR.sup.5, provided that: when W is C, the bond is a double bond and Z is O, or when W is C(OR.sup.4), the bond is a single bond and Z is OR.sup.5, and
wherein R.sup.2 and R.sup.3 are independently selected from a saturated or unsaturated C.sub.1-6 alkyl, a saturated or unsaturated cycloalkyl, or an aryl, each of which may be substituted or unsubstituted, or wherein one of R.sup.2 and R.sup.3 is hydrogen, and the other rest is a saturated or unsaturated C.sub.1-6 alkyl, a saturated or unsaturated cycloalkyl, or an aryl, each of which may be substituted or unsubstituted, or wherein R.sup.2 and R.sup.3 may form a cyclic structure, R.sup.4 and R.sup.5 are independently selected from a C.sub.1-6 alkyl, a cycloalkyl, or an aryl, each of which may be substituted or unsubstituted.