Patent classifications
C07D279/36
SMALL MOLECULE ENHANCEMENT OF 20S PROTEASOME ACTIVITY TARGETS INTRINSICALLY DISORDERED PROTEINS
The disclosure is directed to compounds of the formula (I) and (II) and uses of such compounds to treat, among other conditions, neurodegenerative diseases and cancers.
Photosensitizer and derivatives and application thereof
A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, R.sub.1 and R.sub.2 are independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; R.sub.3 is selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and L.sub.1 is a linker selected from —(CH.sub.2).sub.n1— or —(CH.sub.2CH.sub.2O).sub.n2—. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues. Moreover, clinical anticancer drugs can be introduced into the structure of benzophenothiazine or benzophenoselenazine to achieve the purpose of combining therapy of photodynamic therapy and chemotherapy. ##STR00001##
Organic compound and organic electroluminescence device using the same
An organic compound is described. An organic electroluminescence device comprises the organic compound, as a host of an emissive layer, or as a hole blocking layer. The organic compound may increase a half-life or current efficiency of the organic electroluminescence device. The organic compound may lower a driving voltage of the organic electroluminescence device. The mentioned organic compound may have the following formula: ##STR00001## The same definition as described in the present invention.
Organic compound and organic electroluminescence device using the same
An organic compound is described. An organic electroluminescence device comprises the organic compound, as a host of an emissive layer, or as a hole blocking layer. The organic compound may increase a half-life or current efficiency of the organic electroluminescence device. The organic compound may lower a driving voltage of the organic electroluminescence device. The mentioned organic compound may have the following formula: ##STR00001## The same definition as described in the present invention.
Polymer composition containing diarylamine-based compound
The present invention provides a polymer composition comprising a polymer and an antioxidant comprising a diarylamine-based compound represented by General Formula (1): ##STR00001##
where, in General Formula (1), A.sup.1 and A.sup.2 each independently represent a C.sub.6 to C.sub.18 arylene group which may have a substituent, and A.sup.3 and A.sup.4 each independently represent an organic group having a cyclic imide structure which may have a substituent.
Diarylamine-based compound, anti-aging agent, and polymer composition
The present invention provides a diarylamine-based compound represented by General Formula (1): ##STR00001##
(where A.sup.1 and A.sup.2 each independently represent a C.sub.6 to C.sub.18 arylene group which may have a substituent, and A.sup.3 and A.sup.4 each independently represent an organic group having a cyclic imide structure which may have a substituent).
Substituted phenothiazines as proteasome activators
The disclosure is directed to compounds of the formula (I): ##STR00001##
and uses of such compounds to treat neurodegenerative diseases and cancers.
POLYMER COMPOSITION CONTAINING DIARYLAMINE-BASED COMPOUND
The present invention provides a polymer composition comprising a polymer and an antioxidant comprising a diarylamine-based compound represented by General Formula (1):
##STR00001##
where, in General Formula (1), A.sup.1 and A.sup.2 each independently represent a C.sub.6 to C.sub.18 arylene group which may have a substituent, and A.sup.3 and A.sup.4 each independently represent an organic group having a cyclic imide structure which may have a substituent.
ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME
An organic compound is described. An organic electroluminescence device comprises the organic compound, as a host of an emissive layer, or as a hole blocking layer. The organic compound may increase a half-life or current efficiency of the organic electroluminescence device. The organic compound may lower a driving voltage of the organic electroluminescence device. The mentioned organic compound may have the following formula:
##STR00001##
The same definition as described in the present invention.
ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME
An organic compound is described. An organic electroluminescence device comprises the organic compound, as a host of an emissive layer, or as a hole blocking layer. The organic compound may increase a half-life or current efficiency of the organic electroluminescence device. The organic compound may lower a driving voltage of the organic electroluminescence device. The mentioned organic compound may have the following formula:
##STR00001##
The same definition as described in the present invention.