A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO by providing a composition comprising a compound set forth in Formula (I):

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A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO by providing a composition comprising a compound set forth in Formula (I):

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Disclosed is a gas distribution plate, comprising a metal plate, central openings and peripheral openings, wherein a ratio D1/D1′ of the aperture diameter D1 (expressed in a unit of mm) of the central opening to the aperture diameter D1′ (expressed in a unit of mm) of the peripheral opening satisfies the relation of 1.10≥D1/D1′>1.00. A fluidizing device comprising the gas distribution plate and application of the fluidizing device in an oxidation or ammoxidation reaction process are also disclosed. The gas distribution plate has an advantage of uniform gas distribution.

Disclosed is a gas distribution plate, comprising a metal plate, central openings and peripheral openings, wherein a ratio D1/D1′ of the aperture diameter D1 (expressed in a unit of mm) of the central opening to the aperture diameter D1′ (expressed in a unit of mm) of the peripheral opening satisfies the relation of 1.10≥D1/D1′>1.00. A fluidizing device comprising the gas distribution plate and application of the fluidizing device in an oxidation or ammoxidation reaction process are also disclosed. The gas distribution plate has an advantage of uniform gas distribution.

The present disclosure relates to the field of epoxide synthesis, and particularly to a safe, environmentally friendly and controllable method for preparing cycloaliphatic diepoxides. The method comprises the steps of: mixing a diene compound, a carboxylic acid, an alkaline salt, and a solvent, and cooling; dropwise adding a hydrogen peroxide solution thereto over 1-12 h; standing for layering to obtain an underlayer of an organic phase 1, washing the organic phase 1 with a washing liquid, and standing for layering to obtain an underlayer of an organic phase 2; and purifying the organic phase 2. The reaction system of the present disclosure is simple, environmentally friendly, safe and controllable, and the production cost is low, which can meet the technical and economic requirements. The obtained cycloaliphatic diepoxides have high purity, high yield, low solvent content, low chroma and low halogen content, which are suitable for large-scale industrial production.

This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

Ethylene oxide composition having a recycle content value is obtained by reacting an ethylene stream containing recycle content ethylene to make a recycle content ethylene oxide or by deducting from a recycle inventory a recycle content value applied to ethylene oxide composition. At least a portion of the recycle content value in the feedstock or in an allotment obtained by ethylene oxide M manufacturer has its origin in recycled waste and/or pyrolysis of recycled waste and/or in thermal steam cracking of recycle content pyoil. An alkylene diol composition and/or an alkylene diol polyester composition having a recycle content value that is obtained by reacting a recycle content feedstock to make a recycle content alkylene diol or alkylene diol polyester or by deducting from a recycle inventory a recycle content value applied to an alkylene diol composition and/or alkylene diol polyester. At least a portion of the recycle content value in the feedstock or in an allotment obtained by an alkylene diol or alkylene diol polyester manufacturer has its origin in recycled waste and/or pyrolysis of recycled waste and/or in thermal steam cracking of recycle content pyoil.

Ethylene oxide composition having a recycle content value is obtained by reacting an ethylene stream containing recycle content ethylene to make a recycle content ethylene oxide or by deducting from a recycle inventory a recycle content value applied to ethylene oxide composition. At least a portion of the recycle content value in the feedstock or in an allotment obtained by ethylene oxide M manufacturer has its origin in recycled waste and/or pyrolysis of recycled waste and/or in thermal steam cracking of recycle content pyoil. An alkylene diol composition and/or an alkylene diol polyester composition having a recycle content value that is obtained by reacting a recycle content feedstock to make a recycle content alkylene diol or alkylene diol polyester or by deducting from a recycle inventory a recycle content value applied to an alkylene diol composition and/or alkylene diol polyester. At least a portion of the recycle content value in the feedstock or in an allotment obtained by an alkylene diol or alkylene diol polyester manufacturer has its origin in recycled waste and/or pyrolysis of recycled waste and/or in thermal steam cracking of recycle content pyoil.

A method for producing epoxyalkane includes the step of separating, in a separation column, a stream containing epoxyalkane, extractant, and diol. The separation column operates under conditions so as to enable the extractant and the diol to form an azeotrope, and a stream containing extractant and binary azeotrope is extracted from the side-draw of the separation column to liquid-liquid separation. The method can be used for the industrial production of epoxyalkane.

An ethylene oxide (EO) production process comprising (a) introducing a first reactant mixture (C.sub.2H.sub.6, C.sub.2H.sub.4, O.sub.2) to a first reactor system to produce a first effluent stream (C.sub.2H.sub.4, C.sub.2H.sub.6, O.sub.2), wherein the mole fraction of ethylene in first effluent stream is greater than in first reactant mixture; wherein the first reactor system is characterized by a first reactor system operating temperature of 270° C.-320° C.; wherein the first reactor system comprises oxidative dehydrogenation (ODH) stage(s); (b) introducing the first effluent stream to a second reactor to produce a second effluent stream (EO, C.sub.2H.sub.4, C.sub.2H.sub.6, O.sub.2); (c) separating the second effluent stream into an EO product stream (EO) and recycle stream (C.sub.2H.sub.4, C.sub.2H.sub.6, O.sub.2); wherein ethylene is not separated from recycle stream and/or first effluent stream; (d) recycling at least a portion of recycle stream to the first reactor system, and a optionally portion of recycle stream to the second reactor.