C07D303/18

POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF
20180008630 · 2018-01-11 ·

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF
20180008630 · 2018-01-11 ·

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF
20230165892 · 2023-06-01 · ·

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF
20230165892 · 2023-06-01 · ·

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

REACTION PRODUCTS OF AMINO ACIDS AND EPOXIES
20170218533 · 2017-08-03 ·

Reaction products of one or more amino acids and one or more epoxies are included in copper and copper alloy electroplating baths to provide good throwing power. Such reaction products may plate copper and copper alloys with good surface properties and good physical reliability.

METHOD FOR OBTAINING BIOSOURCED POLYEPOXIDES WITH IMPROVED PROPERTIES

The invention relates to a method for preparing an epoxy prepolymer composition comprising glycidyl ethers, said method comprising the following steps: a) placing a dianhydrohexitol into contact with another alcohol so as to obtain a composition of alcohols; b) reacting the composition of alcohols obtained in step a) with an epihalohydrin so as to obtain a reaction mixture comprising glycidyl ethers; c) recovering the epoxy prepolymer composition comprising glycidyl ethers from the reaction mixture obtained at the end of step b);
The invention also relates to an epoxy prepolymer composition that can be obtained by said method, a curable composition comprising said epoxy prepolymer composition, a polyepoxide obtained by curing said curable composition and a composite material, coating or adhesive comprising said polyepoxide.

METHOD FOR OBTAINING BIOSOURCED POLYEPOXIDES WITH IMPROVED PROPERTIES

The invention relates to a method for preparing an epoxy prepolymer composition comprising glycidyl ethers, said method comprising the following steps: a) placing a dianhydrohexitol into contact with another alcohol so as to obtain a composition of alcohols; b) reacting the composition of alcohols obtained in step a) with an epihalohydrin so as to obtain a reaction mixture comprising glycidyl ethers; c) recovering the epoxy prepolymer composition comprising glycidyl ethers from the reaction mixture obtained at the end of step b);
The invention also relates to an epoxy prepolymer composition that can be obtained by said method, a curable composition comprising said epoxy prepolymer composition, a polyepoxide obtained by curing said curable composition and a composite material, coating or adhesive comprising said polyepoxide.

Phenalene-1-one-containing photosensitizer composition, phenalene-1-one compound and the use thereof
11186545 · 2021-11-30 · ·

A phenalene-1-one compound, a photosensitizer composition including the phenalene-1-one compound, an article including the phenalene-1-one compound and/or photosensitizer composition and the use thereof.

Phenalene-1-one-containing photosensitizer composition, phenalene-1-one compound and the use thereof
11186545 · 2021-11-30 · ·

A phenalene-1-one compound, a photosensitizer composition including the phenalene-1-one compound, an article including the phenalene-1-one compound and/or photosensitizer composition and the use thereof.

Oxygen absorbing agent

An oxygen absorbing agent containing a compound (A) of formula (I): ##STR00001## wherein X is a chalcogen atom, R.sup.1 and R.sup.2 are each any one of an alkyl group which optionally has a substituent, an alkenyl group which optionally has a substituent, an aryl group which optionally has a substituent, and an aralkyl group which optionally has a substituent, R.sup.3 and R.sup.4 are each any one of a hydrogen atom, an alkyl group which optionally has a substituent, an alkenyl group which optionally has a substituent, an aryl group which optionally has a substituent, and an aralkyl group which optionally has a substituent, and R.sup.5 is a polymerizable group; and a transition metal salt (B).