The present invention provides a process for the preparation of 1,4-butanediol and tetrahydrofuran said process comprising contacting furan with hydrogen and water in the presence of a supported catalytic composition comprising rhenium and palladium in a weight ratio of at least 1:1 and a total combined weight rhenium and palladium in the catalyst composition in the range of from 0.01 to 20 wt %.

Provided herein are the K-Ras inhibitors of the formulae: ##STR00001##
Also provided are compositions comprising thereof for treating cancer.

Provided herein are the K-Ras inhibitors of the formulae: ##STR00001##
Also provided are compositions comprising thereof for treating cancer.

Described herein are methods, systems, and techniques relating to clathrate hydrate formation processes and, particularly, involving reactive metal nucleation substrates for promoting clathrate hydrate formation. The disclosed methods, systems, and techniques allow for improved nucleation rate and yield of clathrate hydrates. In some cases, the disclosed methods, systems, and techniques can also improve or reduce the amount of time needed for obtaining a given quantity of clathrate hydrate phase, for example, in desalination, gas separation and/or gas sequestration processes. The reactive metal nucleation substrate may include reactive metals from Group II, Group I, or Group XIII of the periodic table, for example, in alloyed form with other metals and/or nonmetal elements.

Described herein are methods, systems, and techniques relating to clathrate hydrate formation processes and, particularly, involving reactive metal nucleation substrates for promoting clathrate hydrate formation. The disclosed methods, systems, and techniques allow for improved nucleation rate and yield of clathrate hydrates. In some cases, the disclosed methods, systems, and techniques can also improve or reduce the amount of time needed for obtaining a given quantity of clathrate hydrate phase, for example, in desalination, gas separation and/or gas sequestration processes. The reactive metal nucleation substrate may include reactive metals from Group II, Group I, or Group XIII of the periodic table, for example, in alloyed form with other metals and/or nonmetal elements.

A hypergolic co-crystal material for producing a hypergol when combined with an oxidizer; it has co-crystals composed at least of a hypergolic trigger component and an energetic coformer.

A hypergolic co-crystal material for producing a hypergol when combined with an oxidizer; it has co-crystals composed at least of a hypergolic trigger component and an energetic coformer.

The present disclosure encompasses solid state forms of Resmetirom, in embodiments crystalline polymorphs of Resmetirom, processes for preparation thereof, and pharmaceutical compositions thereof.

Provided is a single step process for producing 2-methyltetrahydrofuran from furfuryl alcohol with high conversion rate and high selectivity towards 2-methyltetrahydrofuran.

The present disclosure includes a method of obtaining an alkyltintrihalide, obtaining a solvent, and contacting the alkyltintrihalide and the solvent, thereby forming an alkyltintrihalide adduct. Also described is a composition including: an alkyltintrihalide adduct of the formula: RSnX.sub.3.Math.(solv).sub.n, wherein: R is a substituted C.sub.1-C.sub.5 alkyl, an unsubstituted C.sub.1-C.sub.5 alkyl, a substituted C.sub.1-C.sub.5 alkenyl, or an unsubstituted C.sub.1-C.sub.5 alkenyl; X is Cl, Br, or I; solv is a solvent; and n is at least 1.