Patent classifications
C07D311/34
Chromone inhibitors of S-nitrosoglutathione reductase
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
Chromone inhibitors of S-nitrosoglutathione reductase
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
Kinase modulators
The present invention provides PI3K protein kinase modulators of Formula (I) ##STR00001##
wherein R, n, R.sup.1, R.sup.2, L.sup.1, Cy.sup.1 and Cy.sup.2 are as defined herein, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
Multitarget hedgehog pathway inhibitors and uses thereof
The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
Multitarget hedgehog pathway inhibitors and uses thereof
The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).