The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I). ##STR00001##

The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

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The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

A method of cannabinoid preservation includes separating a cannabinoid ethanol (EtOH) mixture from a cannabis extract through a filtration process; forming a slurry by combining a crystalline compound with the cannabinoid EtOH mixture; heating and agitating the slurry in a pressurized chamber to form a colloidal cannabinoid EtOH mixture; distributing the colloidal cannabinoid EtOH mixture into a tray to form an evenly distributed mixture layer; forming an evaporation vessel for the evenly distributed mixture layer through the attachment of a detachable cover to the tray; positioning and heating the evaporation vessel within a heating chamber; performing a rapid cools process as the evenly distributed mixture layer approaches approaches saturation temperature; repeating the rapid cooling process until crystal formation is detected within the evenly distributed mixture layer; and/or removing the evaporation vessel from the heating chamber upon detection of crystal formation.

A method of cannabinoid preservation includes separating a cannabinoid ethanol (EtOH) mixture from a cannabis extract through a filtration process; forming a slurry by combining a crystalline compound with the cannabinoid EtOH mixture; heating and agitating the slurry in a pressurized chamber to form a colloidal cannabinoid EtOH mixture; distributing the colloidal cannabinoid EtOH mixture into a tray to form an evenly distributed mixture layer; forming an evaporation vessel for the evenly distributed mixture layer through the attachment of a detachable cover to the tray; positioning and heating the evaporation vessel within a heating chamber; performing a rapid cools process as the evenly distributed mixture layer approaches approaches saturation temperature; repeating the rapid cooling process until crystal formation is detected within the evenly distributed mixture layer; and/or removing the evaporation vessel from the heating chamber upon detection of crystal formation.

The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

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The invention relates to a method for separating natural substance mixtures, in particular those consisting of plant extracts, and for isolating and purifying and obtaining same, by means of sequential centrifugal partition chromatography (sCPC).

The invention relates to a method for separating natural substance mixtures, in particular those consisting of plant extracts, and for isolating and purifying and obtaining same, by means of sequential centrifugal partition chromatography (sCPC).

Disclosed are chromane compounds, analogs thereof, and methods of their synthesis and use. The compounds may be synthesized by methods involving reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis. The compounds may be formulated in a pharmaceutical composition for treating one of the aforementioned diseases or disorders.

Disclosed are chromane compounds, analogs thereof, and methods of their synthesis and use. The compounds may be synthesized by methods involving reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis. The compounds may be formulated in a pharmaceutical composition for treating one of the aforementioned diseases or disorders.