Chemical modulators of PP2A, comprising tricyclic sulfonimidamides are disclosed. The compounds are useful in preventing or treating cancer, diabetes, autoimmune disease, solid organ transplant rejection, graft vs host disease, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease, abdominal aortic aneurysm, chronic liver disease, heart failure, neurodegenerative disease and cardiac hypertrophy. The compounds are of formula (I)

##STR00001##

The present invention relates to a composition comprising a compound of formula (I) wherein X is selected from the group consisting of S, Se, P, PO, SO, NR.sup.1, CR.sup.1, CR.sup.1R.sup.1 or C.sub.0-2-alkyl; Z is selected from the group consisting of hydrogen, a halogen, SR.sup.4, OR.sup.4, COR.sup.4 where R.sup.4 is a C.sub.1-12-alkyl; each R.sup.2 is independently selected from the group consisting of C.sub.1-6-alkyl, halogen, C.sub.3-8-cycloalkyl, OH, NH.sub.2, NHR.sup.1, N(R.sup.1).sub.2, O—C.sub.1-6-alkyl, O—C.sub.3-8-cycloalkyl, NH—C.sub.1-6-alkyl, NH—C.sub.3-8-cycloalkyl, S—C.sub.1-6-alkyl, S—C.sub.3-8-cycloalkyl, aryl, heteroaryl, aryloxy, heteroaryloxy, arylamino, heteroarylamino, arylalkyl, heteroarylalkyl, arylalkyloxy and heteroarylalkyloxy; d is selected from 0, 1, 2, and 3; each R.sup.3 is independently selected from the group consisting of C.sub.1-6-alkyl, halogen, C.sub.3-8-cycloalkyl, OH, NH.sub.2, NHR.sup.1, N(R.sup.1).sub.2, O—C.sub.1-6-alkyl, O—C.sub.3-8-cycloalkyl, NH—C.sub.1-6-alkyl, NH—C.sub.3-8-cycloalkyl, S—C.sub.1-6-alkyl, S-C3-8-cycloalkyl, aryl, heteroaryl, aryloxy, heteroaryloxy, arylamino, heteroarylamino, arylalkyl, heteroarylalkyl, arylalkyloxy and heteroarylalkyloxy; e is selected from 0, 1, 2, 3, and 4; R.sup.1 is selected from the group consisting of C.sub.1-6-alkyl, C.sub.3-8-cycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl; R.sup.5 is N—(CHW)—N(Y.sup.1)(Y.sup.2)(Y.sup.3) or C═CH—(CHW)—N(Y.sup.1)(Y.sup.2)(Y.sup.3); each W is individually selected from the group consisting of linear or branched C.sub.1-6-alkyl or together with the nitrogen atom —N(Y.sup.1)(Y.sup.2)(Y.sup.3)— to which it is attached forms an optionally substituted nitrogen-containing heteroaryl or optionally substituted nitrogen-containing heterocyclyl together with Y.sup.1 where; Y.sup.1 is selected from the group consisting of C.sub.1-12-alkyl or together with the W and the nitrogen atom to which it is attached forms an optionally substituted nitrogen-containing heteroaryl or optionally substituted nitrogen-containing heterocyclyl; Y.sup.2 is selected from the group consisting of C.sub.1-12-alkyl; Y.sup.3 is selected from the group consisting of linear or branched C.sub.2-25-alkyl, linear or branched C.sub.2-25 alkenyl or linear or branched C.sub.2-25 alkynyl; where A is selected from any pharmaceutical relevant/acceptable anion/counterion; wherein if X is S and Z is a halogen then Y.sup.3 cannot be a C.sub.2-alkyl or a branched C.sub.3-alkyl; wherein if X is S and Z is hydrogen then Y.sup.3 cannot be C.sub.2-alkyl or linear or branched C.sub.5-alkyl. The invention also relates to anti-microbial composition fo

The present invention relates to a composition comprising a compound of formula (I) wherein X is selected from the group consisting of S, Se, P, PO, SO, NR.sup.1, CR.sup.1, CR.sup.1R.sup.1 or C.sub.0-2-alkyl; Z is selected from the group consisting of hydrogen, a halogen, SR.sup.4, OR.sup.4, COR.sup.4 where R.sup.4 is a C.sub.1-12-alkyl; each R.sup.2 is independently selected from the group consisting of C.sub.1-6-alkyl, halogen, C.sub.3-8-cycloalkyl, OH, NH.sub.2, NHR.sup.1, N(R.sup.1).sub.2, O—C.sub.1-6-alkyl, O—C.sub.3-8-cycloalkyl, NH—C.sub.1-6-alkyl, NH—C.sub.3-8-cycloalkyl, S—C.sub.1-6-alkyl, S—C.sub.3-8-cycloalkyl, aryl, heteroaryl, aryloxy, heteroaryloxy, arylamino, heteroarylamino, arylalkyl, heteroarylalkyl, arylalkyloxy and heteroarylalkyloxy; d is selected from 0, 1, 2, and 3; each R.sup.3 is independently selected from the group consisting of C.sub.1-6-alkyl, halogen, C.sub.3-8-cycloalkyl, OH, NH.sub.2, NHR.sup.1, N(R.sup.1).sub.2, O—C.sub.1-6-alkyl, O—C.sub.3-8-cycloalkyl, NH—C.sub.1-6-alkyl, NH—C.sub.3-8-cycloalkyl, S—C.sub.1-6-alkyl, S-C3-8-cycloalkyl, aryl, heteroaryl, aryloxy, heteroaryloxy, arylamino, heteroarylamino, arylalkyl, heteroarylalkyl, arylalkyloxy and heteroarylalkyloxy; e is selected from 0, 1, 2, 3, and 4; R.sup.1 is selected from the group consisting of C.sub.1-6-alkyl, C.sub.3-8-cycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl; R.sup.5 is N—(CHW)—N(Y.sup.1)(Y.sup.2)(Y.sup.3) or C═CH—(CHW)—N(Y.sup.1)(Y.sup.2)(Y.sup.3); each W is individually selected from the group consisting of linear or branched C.sub.1-6-alkyl or together with the nitrogen atom —N(Y.sup.1)(Y.sup.2)(Y.sup.3)— to which it is attached forms an optionally substituted nitrogen-containing heteroaryl or optionally substituted nitrogen-containing heterocyclyl together with Y.sup.1 where; Y.sup.1 is selected from the group consisting of C.sub.1-12-alkyl or together with the W and the nitrogen atom to which it is attached forms an optionally substituted nitrogen-containing heteroaryl or optionally substituted nitrogen-containing heterocyclyl; Y.sup.2 is selected from the group consisting of C.sub.1-12-alkyl; Y.sup.3 is selected from the group consisting of linear or branched C.sub.2-25-alkyl, linear or branched C.sub.2-25 alkenyl or linear or branched C.sub.2-25 alkynyl; where A is selected from any pharmaceutical relevant/acceptable anion/counterion; wherein if X is S and Z is a halogen then Y.sup.3 cannot be a C.sub.2-alkyl or a branched C.sub.3-alkyl; wherein if X is S and Z is hydrogen then Y.sup.3 cannot be C.sub.2-alkyl or linear or branched C.sub.5-alkyl. The invention also relates to anti-microbial composition fo

The present invention relates to compounds of formula (1) which are suitable for use in electronic devices, especially in organic electroluminescent devices.

The present invention relates to compounds of formula (1) which are suitable for use in electronic devices, especially in organic electroluminescent devices.

A light-emitting device includes a first electrode, a second electrode facing the first electrode, and an interlayer including an emission layer between the first electrode and the second electrode and a hole transport region between the first electrode and the emission layer, wherein the emission layer may include a dopant, the hole transport region may include a first hole transport layer, a second hole transport layer between the first hole transport layer and the emission layer, and a third hole transport layer between the second hole transport layer and the emission layer, the first hole transport layer may include a first compound, the second hole transport layer may include a second compound, the third hole transport layer may include a third compound, and the first to third compounds may each independently be an amine-based compound, but may be different from each other.

Described are polymerizable high energy light absorbing compounds. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Described are polymerizable high energy light absorbing compounds. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Described are polymerizable fused tricyclic compounds of formula I:

##STR00001##

wherein R.sup.1, R.sup.2, R.sup.3, m, n, t, and rings B, C, and D are as defined herein. The compounds absorb various wavelengths of ultraviolet and/or visible light (such as high energy visible light) and are suitable for incorporation in a variety of products, such as biomedical devices and ophthalmic devices.

Described are polymerizable fused tricyclic compounds of formula I:

##STR00001##

wherein R.sup.1, R.sup.2, R.sup.3, m, n, t, and rings B, C, and D are as defined herein. The compounds absorb various wavelengths of ultraviolet and/or visible light (such as high energy visible light) and are suitable for incorporation in a variety of products, such as biomedical devices and ophthalmic devices.