The invention relates to novel compounds of the formula (I)

##STR00001## in which the R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, A.sup.1, A.sup.2, A.sup.3, A.sup.4 and n radicals are each as defined above, to their use as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for their preparation.

The invention relates to novel compounds of the formula (I)

##STR00001## in which the R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, A.sup.1, A.sup.2, A.sup.3, A.sup.4 and n radicals are each as defined above, to their use as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for their preparation.

Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.

Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.

The present disclosure provides pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

The present disclosure provides pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

The invention relates to novel compounds of the formula (I)

##STR00001##

in which R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 and n radicals are each as defined above,

to the use thereof as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for preparation thereof.

The invention relates to novel compounds of the formula (I)

##STR00001##

in which R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 and n radicals are each as defined above,

to the use thereof as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for preparation thereof.

Treatment of neurodegenerative diseases is achieved using small molecule purine scaffold compounds that inhibit Hsp90 and that possess the ability to cross the blood-brain barrier or are otherwise delivered to the brain.

Treatment of neurodegenerative diseases is achieved using small molecule purine scaffold compounds that inhibit Hsp90 and that possess the ability to cross the blood-brain barrier or are otherwise delivered to the brain.