Porphyrin photosensitizers including 5,15-di(naphthalimide) moieties useful for photocatalytic hydrogen evolution, compositions including the same, and methods of use thereof.

Disclosed are a compound as represented by general formula (I), a cis-trans isomer thereof, an enantiomer thereof, a diastereoisomer thereof, a racemate thereof, a solvate thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof or a prodrug thereof, a preparation method therefor, a pharmaceutical composition comprising the compound and the use of the compound as an Lp-PLA.sub.2 inhibitor

##STR00001##

This invention provides unnatural amino acids as well as amino acid sequences, foldamers, macrocycles, and formulations comprising said unnatural amino acids. In one aspect of the invention, the unnatural amino acids or the formulation thereof are used to mimic natural amino acids or the formulations thereof in a subject in need thereof.

This invention provides unnatural amino acids as well as amino acid sequences, foldamers, macrocycles, and formulations comprising said unnatural amino acids. In one aspect of the invention, the unnatural amino acids or the formulation thereof are used to mimic natural amino acids or the formulations thereof in a subject in need thereof.

A compound represented by the following formulas (1-1) and (1-3), or a compound represented by the following formulas (1-2) and (1-3). At least one of R.sub.1 to R.sub.16 is a substituted or unsubstituted alkyl group including 1 to 50 carbon atoms or the like. In the compound represented by the formulas (1-1) and (1-3), at least one of R.sub.5 to R.sub.7 and R.sub.14 to R.sub.16 is —N(R.sub.36)(R.sub.37), and in the compound represented by the formulas (1-2) and (1-3), at least one of R.sub.2 to R.sub.16 is —N(R.sub.36)(R.sub.37).

##STR00001##

A compound represented by the following formulas (1-1) and (1-3), or a compound represented by the following formulas (1-2) and (1-3). At least one of R.sub.1 to R.sub.16 is a substituted or unsubstituted alkyl group including 1 to 50 carbon atoms or the like. In the compound represented by the formulas (1-1) and (1-3), at least one of R.sub.5 to R.sub.7 and R.sub.14 to R.sub.16 is —N(R.sub.36)(R.sub.37), and in the compound represented by the formulas (1-2) and (1-3), at least one of R.sub.2 to R.sub.16 is —N(R.sub.36)(R.sub.37).

##STR00001##

An organic electroluminescence device comprising: a cathode, an anode, and at least one organic layer disposed between the cathode and the anode, wherein at least one layer of the at least one organic layer comprises a compound represented by the following formulas (1-1) and (1-3) or a compound represented by the following formulas (1-2) and (1-3). ##STR00001##

An organic electroluminescence device comprising: a cathode, an anode, and at least one organic layer disposed between the cathode and the anode, wherein at least one layer of the at least one organic layer comprises a compound represented by the following formulas (1-1) and (1-3) or a compound represented by the following formulas (1-2) and (1-3). ##STR00001##

Provided are certain TRK inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Provided are certain TRK inhibitors, pharmaceutical compositions thereof, and methods of use thereof.