8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH.sub.2—OH, —CH.sub.2NH.sub.2, —NHSO.sub.2CH.sub.3,

##STR00001##

and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.

##STR00002##

8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.

The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.

The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.

The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula: ##STR00001##
or a pharmaceutically acceptable salt or solvate thereof, wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and X are as defined in the specification.

The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula: ##STR00001##
or a pharmaceutically acceptable salt or solvate thereof, wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and X are as defined in the specification.

8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is CH.sub.2OH, CH.sub.2NH.sub.2, NHSO.sub.2CH.sub.3, ##STR00001##
and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. ##STR00002##
8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.

The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: ##STR00001##
or a pharmaceutically acceptable salt or solvate thereof, wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and X are as defined in the specification.

The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: ##STR00001##
or a pharmaceutically acceptable salt or solvate thereof, wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and X are as defined in the specification.

The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula:

##STR00001##

or a pharmaceutically acceptable salt or solvate thereof, wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and X are as defined in the specification.

The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula:

##STR00001##

or a pharmaceutically acceptable salt or solvate thereof, wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and X are as defined in the specification.