Patent classifications
C07D491/04
COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: Formula AA or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.
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Materials for organic electroluminescent devices
The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
Materials for organic electroluminescent devices
The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
Inhibitors of SARM1
The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
Composition for organic electronic devices
The present invention relates to a composition which comprises an electron-transporting host and a hole-transporting host, to the use thereof in electronic devices and to electronic devices containing this composition. The electron-transporting host is particularly preferably selected from the class of the triazine-dibenzofuran-carbazole systems or the class of the triazine-dibenzothiophene-carbazole systems. The hole-transporting host is preferably selected from the class of the biscarbazoles.
FUROQUINOLINEDIONES AS INHIBITORS OF TDP2
Compounds of Formula I and the pharmaceutically acceptable salts thereof are disclosed Formula I. The variables X.sup.1, X.sup.2, and R.sup.1-4 are disclosed herein. The compounds are useful for treating cancer and related proliferative diseases. Pharmaceutical compositions containing compounds of Formula I and methods of treatment comprising administering compounds of Formula I are also disclosed.
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COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
- Nadiya Sydorenko ,
- Rauful Alam ,
- Suresh Babu ,
- Anuradha Bhattacharyya ,
- Guangming Chen ,
- Matteo Chierchia ,
- Gary Mitchell Karp ,
- Tom Tuan Luong ,
- Anthony R. Mazzotti ,
- Young-Choon Moon ,
- Nicholas Walter Mszar ,
- Jana Narasimhan ,
- Jigar S. Patel ,
- Hongyu Ren ,
- Gang Wang ,
- Matthew G. Woll ,
- Nanjing Zhang ,
- Xiaoyan Zhang
The present description relates to compounds of Formula (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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Isoquinolines as inhibitors of HPK1
- Bryan Chan ,
- Joy Drobnick ,
- Lewis Gazzard ,
- Timothy Heffron ,
- Jun Liang ,
- Sushant Malhotra ,
- Rohan Mendonca ,
- Naomi Rajapaksa ,
- Craig Stivala ,
- John Tellis ,
- Weiru Wang ,
- BinQing Wei ,
- Aihe Zhou ,
- Matthew W. Cartwright ,
- Michael Lainchbury ,
- Emanuela Gancia ,
- Eileen Seward ,
- Andrew Madin ,
- David Favor ,
- Kin Chiu Fong ,
- Yonghan Hu ,
- Andrew Good
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
Isoquinolines as inhibitors of HPK1
- Bryan Chan ,
- Joy Drobnick ,
- Lewis Gazzard ,
- Timothy Heffron ,
- Jun Liang ,
- Sushant Malhotra ,
- Rohan Mendonca ,
- Naomi Rajapaksa ,
- Craig Stivala ,
- John Tellis ,
- Weiru Wang ,
- BinQing Wei ,
- Aihe Zhou ,
- Matthew W. Cartwright ,
- Michael Lainchbury ,
- Emanuela Gancia ,
- Eileen Seward ,
- Andrew Madin ,
- David Favor ,
- Kin Chiu Fong ,
- Yonghan Hu ,
- Andrew Good
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
HIV INHIBITOR COMPOUNDS
The invention provides a compound of Formula I:
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or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.