The present invention relates to a highly convergent method for the synthesis and purification of ceftolozane and intermediates starting from 7-aminocephaiosporanic acid (7-ACA).

The present invention relates to a highly convergent method for the synthesis and purification of ceftolozane and intermediates starting from 7-aminocephaiosporanic acid (7-ACA).

The present invention relates to a highly convergent method for the synthesis and purification of ceftolozane and intermediates starting from 7-aminocephaiosporanic acid (7-ACA).

The present invention relates to a highly convergent method for the synthesis and purification of ceftolozane and intermediates starting from 7-aminocephaiosporanic acid (7-ACA).

The present invention provides a compound exhibiting a strong antimicrobial spectrum against various bacteria, including gram-negative bacteria, or a pharmaceutical composition having an antimicrobial activity carbapenem-resistant bacteria. Provided is a compound represented by formula (I), an ester thereof or a pharmaceutically acceptable salt thereof, or a hydrate thereof. (I) (in the formula, W is S(O) or S(O).sub.2, -T- is CR.sup.4AR.sup.4B or CR.sup.5AR.sup.5BCR.sup.6AR.sup.6B, each of R.sup.2A and R.sup.2B is independently a hydrogen atom, etc., or R.sup.2A and R.sup.2B together form a substituted or unsubstituted methylidene, etc., R.sup.3 is a hydrogran atom, etc., R.sup.11 is a carboxyl, etc., and each of R.sup.7A and R.sup.7B is independently a hydrogen atom, etc.)

The present invention provides a compound exhibiting a strong antimicrobial spectrum against various bacteria, including gram-negative bacteria, or a pharmaceutical composition having an antimicrobial activity carbapenem-resistant bacteria. Provided is a compound represented by formula (I), an ester thereof or a pharmaceutically acceptable salt thereof, or a hydrate thereof. (I) (in the formula, W is S(O) or S(O).sub.2, -T- is CR.sup.4AR.sup.4B or CR.sup.5AR.sup.5BCR.sup.6AR.sup.6B, each of R.sup.2A and R.sup.2B is independently a hydrogen atom, etc., or R.sup.2A and R.sup.2B together form a substituted or unsubstituted methylidene, etc., R.sup.3 is a hydrogran atom, etc., R.sup.11 is a carboxyl, etc., and each of R.sup.7A and R.sup.7B is independently a hydrogen atom, etc.)