Patent classifications
C07D505/20
Method for manufacturing 7alpha-alkoxyoxacephem intermediate compound
The present disclosure provides a method for preparing a 7-alkoxyoxacephem intermediate compound, the method comprising a process (S1) including: reacting a compound represented by a following chemical formula 1 with a halogen compound in an organic solvent to form a reaction product such that unreacted halogen compound remains; and adding metal alkoxide and reducing agent to the reaction product with the unreacted halogen compound remaining, thereby to produce a compound represented by a following chemical formula 2: ##STR00001##
where R is a Cl, Br, I, halogen derivative, R.sub.1 is a carboxyl protecting group including diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H), and R.sub.2 is an alkyl group having 1 to 4 carbon atoms.
Method for manufacturing 7alpha-alkoxyoxacephem intermediate compound
The present disclosure provides a method for preparing a 7-alkoxyoxacephem intermediate compound, the method comprising a process (S1) including: reacting a compound represented by a following chemical formula 1 with a halogen compound in an organic solvent to form a reaction product such that unreacted halogen compound remains; and adding metal alkoxide and reducing agent to the reaction product with the unreacted halogen compound remaining, thereby to produce a compound represented by a following chemical formula 2: ##STR00001##
where R is a Cl, Br, I, halogen derivative, R.sub.1 is a carboxyl protecting group including diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H), and R.sub.2 is an alkyl group having 1 to 4 carbon atoms.
METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND
The present disclosure provides a method for preparing a 7-alkoxyoxacephem intermediate compound, the method comprising a process (S1) including: reacting a compound represented by a following chemical formula 1 with a halogen compound in an organic solvent to form a reaction product such that unreacted halogen compound remains; and adding metal alkoxide and reducing agent to the reaction product with the unreacted halogen compound remaining, thereby to produce a compound represented by a following chemical formula 2:
##STR00001## where R is a Cl, Br, I, halogen derivative, R.sub.1 is a carboxyl protecting group including diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H), and R.sub.2 is an alkyl group having 1 to 4 carbon atoms.
METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND
The present disclosure provides a method for preparing a 7-alkoxyoxacephem intermediate compound, the method comprising a process (S1) including: reacting a compound represented by a following chemical formula 1 with a halogen compound in an organic solvent to form a reaction product such that unreacted halogen compound remains; and adding metal alkoxide and reducing agent to the reaction product with the unreacted halogen compound remaining, thereby to produce a compound represented by a following chemical formula 2:
##STR00001## where R is a Cl, Br, I, halogen derivative, R.sub.1 is a carboxyl protecting group including diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H), and R.sub.2 is an alkyl group having 1 to 4 carbon atoms.