The present invention relates to compounds of formula (I). The compounds maybe used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections. ##STR00001##

The present subject matter provides a safe alternative for producing an important intermediate useful for preparing the herbicide glufosinate, without need for chlorine components in the manufacturing process. In particular, a process for preparing alkyl phosphinic aid alkyl ester is provided, including the step of alkylating alkyl phosphinic acid ester in a non-polar solvent in the same apparatus as used to first produce the alkyl phosphinic acid ester, and without isolating the alkyl phosphinic acid ester before the alkylation step is conducted. More specifically, a process is presented for preparing methyl phosphinic acid butyl ester, by alkylating butyl phosphinic acid ester in a non-polar solvent, in the same apparatus as used previously to first produce the butyl phosphinic acid ester and without isolating the butylphosphinic acid ester before alkylation.

A method for producing methyldichlorophosphane, the method including: allowing methane and phosphorus trichloride to react in the presence of an additive using a metal compound, or a metal compound carried on a carrier, or both thereof.

A method for producing methyldichlorophosphane, the method including: allowing methane and phosphorus trichloride to react in the presence of an additive using a metal compound, or a metal compound carried on a carrier, or both thereof.

A method for producing methyldichlorophosphane, the method including: allowing methane and phosphorus trichloride to react in the presence of an additive using a metal compound, or a metal compound carried on a carrier, or both thereof.

A method for producing methyldichlorophosphane, the method including: allowing methane and phosphorus trichloride to react in the presence of an additive using a metal compound, or a metal compound carried on a carrier, or both thereof.

A method for producing methyldichlorophosphane, the method including: allowing methane and phosphorus trichloride to react in the presence of an additive using a metal compound, or a metal compound carried on a carrier, or both thereof.

A method for producing methyldichlorophosphane, the method including: allowing methane and phosphorus trichloride to react in the presence of an additive using a metal compound, or a metal compound carried on a carrier, or both thereof.

The present invention relates to a non-aqueous electrolyte solution additive, and a non-aqueous electrolyte solution for a lithium secondary battery and a lithium secondary battery which comprise the same, wherein, specifically, since the non-aqueous electrolyte solution, which comprises a compound capable of maintaining a passive effect by increasing an effect of forming a solid electrolyte interface (SEI) on surfaces of a positive electrode and a negative electrode, is provided, high-temperature storage characteristics and life characteristics of the lithium secondary battery may be improved.

The present invention refers to a process for the preparation of a bis(acyl)phosphinic acid silyl ester of the general formula (I), wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 are the same or different and are independently selected from H, halogen, linear or branched C.sub.1-C.sub.20-alkyl, linear or branched C.sub.2-C.sub.8-alkenyl, C.sub.1-C.sub.8-alkoxy, C.sub.2-C.sub.8-alkenyloxy, C.sub.3-C.sub.8-cycloalkyl, C.sub.6-C.sub.12-aryl, C.sub.3-C.sub.8-cycloalkoxy, C.sub.7-C.sub.12-arylalkoxy, C.sub.9-C.sub.15-alkenylarylalkoxy, nitro-, C.sub.6-C.sub.12-arylsulfonyl, 4-alkylarylsulfonyl, C.sub.1-C.sub.20-alkylcarboxy, C.sub.1-C.sub.8-alkoxycarbonyl, SR.sub.12, NHR.sub.12 or NR.sub.12R.sub.13 with R.sub.12 and R.sub.13 being independently selected from H, linear or branched C.sub.1-C.sub.20-alkyl, linear or branched C.sub.2-C.sub.8-alkenyl and C.sub.3-C.sub.8-cycloalkyl, and an O-, S- or N-containing 5- or 6-membered heterocyclic ring; R.sub.6 is OSiR.sub.14R.sub.15R.sub.16 with R.sub.14, R.sub.15 and R.sub.16 being independently selected from linear or branched C.sub.1-C.sub.20-alkyl or C.sub.6-C.sub.12-aryl; as well as the bis(acyl)phosphinic acid silyl ester and the bis(acyl)phosphinic acid obtained by the process. ##STR00001##