Hydrocarbyl tin complexs of alkynyl phosphonic acid with antitumor activity and their application are provided. Tests are conducted to evaluate activity, showing that the provided complexs have much stronger activity than cisplatin. The provided hydrocarbyl tin complexs can be potential candidate as a clinical antitumor drug.

The invention relates to novel silane compounds corresponding to the formula (I) below:
A-E-X (I)
in which: X represents a silyl group capable of creating a covalent bond after reaction with the hydroxyl or hydride functional groups of a support; E represents an organic spacer group; A represents a group chosen from the groups of formulae below: ##STR00001##
in which: Z.sub.1 to Z.sub.5 independently represent a hydrogen atom or a halogen atom; Z.sub.6 and Z.sub.7 represent a group for protecting the phosphonic acid functional group, a hydrogen atom or a monovalent cation; Z.sub.8 to Z.sub.12 independently represent a group for protecting the carboxylic acid functional group, a hydrogen atom or a monovalent cation; and Z.sub.13 represents an imidazole, N-hydroxysuccinimide, nitrophenyl, pentafluorophenyl or acid anhydride group. Use of these silane compounds for functionalizing solid supports and for immobilizing biological molecules on these supports.