The present invention relates to macromolecular transition metal complexes, characterized by having the general formula (I), to the process for their preparation, and to bidentate and monodentate macroligands. The invention also refers to pharmaceutical compositions and medicaments containing said macromolecular transition metal complexes, and to the use of said pharmaceutical compositions, medicaments and macromolecular transition metal complexes for cancer therapy and/or cancer prevention, as antitumor agent in solid tumors, liquid tumors and/or metastases and/or as radiosensitizer agents.

Methods of preparing primary phosphine products using one or more precursor cyclophosphanes, hydrogen, and one or more Lewis acid catalysts. In some embodiments, a cyclophosphane precursor and at least one Lewis acid are dissolved in a solvent to provide a solution. The solution is treated with hydrogen, and optionally heated, to cause a reaction that produces a primary phosphine © product. The primary phosphine product may be isolated from the Lewis acid(s) and optionally purified. In some embodiments, a method may include synthesizing the cyclophosphane precursor prior to mixing the cyclophosphane precursor and the Lewis acid(s).

Provided are a method for preparing L-glufosinate and the intermediate compounds of formula (V) and formula (III).

Provided is an L-glucose derivative represented by General Formula (1) below:

##STR00001## wherein X.sup.1 represents a —SAuR.sup.1 group, and X.sup.2, X.sup.3, X.sup.4 and X.sup.5 each independently represent an —OR.sup.2 group, an —NH.sup.2 group, or a fluorine atom; and R.sup.1 represents a ligand and R.sup.2 represents a hydrogen atom or an organic group.

Provided are a method for preparing L-glufosinate and the intermediate compounds of formula (V) and formula (III).

There is provided a novel optically active bisphosphinomethane useful as a ligand for an asymmetric catalyst, excellent in oxidation resistance in air, and easy in handling. There is also provided a transition metal complex using the optically active bisphosphinoraethane having excellent asymmetric catalytic ability as a ligand. The optically active bisphosphinomethane is represented by the general formula (1), and the transition metal complex has the optically active bisphosphinomethane as a ligand. ##STR00001##
(In the formula, R.sup.1 represents an adamantyl group; R.sup.2 represents a branched alkyl group having 3 or more carbon atoms; and * represents an asymmetric center on a phosphorus atom.)

An electrolyte including at least a compound of formula I:

##STR00001##

A.sup.1, A.sup.2, and A.sup.3 are each independently selected from the following formulas I-A, I-B, I-C, or I-D, and the A.sup.1, A.sup.2, and A.sup.3 are not all I-A:

##STR00002##

m and k are 0 or 1, and n is integer from 1 to 6. R.sup.11, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.1a, R.sup.1b, R.sup.1c, and R.sup.1d are selected from hydrogen; substituted or unsubstituted C.sub.1-C.sub.10 alkylidene groups, C.sub.2-C.sub.10 alkenylene groups, C.sub.2-C.sub.10 alkynylidene groups, C.sub.3-C.sub.10 cumulative dienyl groups, C.sub.6-C.sub.10 aryl groups, or C.sub.3-C.sub.10 alicyclic hydrocarbon groups. R.sup.12 is selected from substituted or unsubstituted C.sub.1-C.sub.10 alkyl groups, C.sub.2-C.sub.10 alkenyl groups, C.sub.2-C.sub.10 alkynyl groups, C.sub.3-C.sub.10 cumulative dienyl groups, C.sub.6-C.sub.10 aryl groups, C.sub.3-C.sub.10 alicyclic hydrocarbon groups, or heteroatom-containing functional groups.

N.sup.2-phosphinyl amidine compounds, N.sup.2-phosphinyl amidinates, N.sup.2-phosphinyl amidine metal salt complexes, N.sup.2-phosphinyl amidinate metal salt complexes are described. Methods for making N.sup.2-phosphinyl amidine compounds, N.sup.2-phosphinyl amidinates, N.sup.2-phosphinyl amidine metal salt complexes, and N.sup.2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N.sup.2-phosphinyl amidine metal salt complexes and N.sup.2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N.sup.2-phosphinyl amidine compounds, N.sup.2-phosphinyl amidinates, N.sup.2-phosphinyl amidine metal salt complexes, and N.sup.2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.

The invention relates to lithium alkyl aluminates according to the general formula Li[AlR.sub.4] and to a method for preparing same, starting from LiAlH.sub.4 and RLi in an aprotic solvent. The invention also relates to compounds according to the general formula Li[AlR.sub.4] which can be obtained using the claimed method, and to the use thereof. The invention also relates to the use of a lithium alkyl aluminate Li[AlR.sub.4] as a transfer reagent for transferring at least one radical R to an element halide or metal halide and to a method for transferring at least one radical R to a compound E(X).sub.q for preparing a compound according to the general formula E(X).sub.q-pR.sub.p, where E=aluminium, gallium, indium, thallium, germanium, tin, lead, antimony, bismuth, zinc, cadmium, mercury, or phosphorus, X=halogen, q=2, 3 or 4, and p=1, 2, 3 or 4. The invention also relates to compounds which can be obtained using such a method, to the use thereof, and to a substrate which has an aluminium layer or a layer containing aluminium on one surface.

There is provided a novel optically active bisphosphinomethane useful as a ligand for an asymmetric catalyst, excellent in oxidation resistance in air, and easy in handling. There is also provided a transition metal complex using the optically active bisphosphinoraethane having excellent asymmetric catalytic ability as a ligand. The optically active bisphosphinomethane is represented by the general formula (1), and the transition metal complex has the optically active bisphosphinomethane as a ligand.

##STR00001##

(In the formula, R.sup.1 represents an adamantyl group; R.sup.2 represents a branched alkyl group having 3 or more carbon atoms; and * represents an asymmetric center on a phosphorus atom.)