Preparation of phosphorus fine chemicals from phosphate sources is described.

The present invention relates to an improved process for the preparation of tetrofosmin or acid addition salt thereof. The present invention also relates to the process for the preparation of tetrofosmin disulfosalicylate salt. Further the present invention also provides the polymorphic form J of disulfosalicylate salt of tetrofosmin.

Provided is a process for the conversion of a tertiary phosphine oxide to the corresponding tertiary phosphine, comprising at least reacting said tertiary phosphine oxide with a phosphite compound, in the presence of at least a catalyst. Furthermore, provided is a composition comprising at least a tertiary phosphine oxide and a phosphite compound, and optionally a catalyst.

Provided is a process for the conversion of a tertiary phosphine oxide to the corresponding tertiary phosphine, comprising at least reacting said tertiary phosphine oxide with a phosphite compound, in the presence of at least a catalyst. Furthermore, provided is a composition comprising at least a tertiary phosphine oxide and a phosphite compound, and optionally a catalyst.

The present invention relates to an improved process for the preparation of tetrofosmin or acid addition salt thereof. The present invention also relates to the process for the preparation of tetrofosmin disulfosalicylate salt. Further the present invention also provides the polymorphic form J of disulfosalicylate salt of tetrofosmin.

Preparation of phosphorus fine chemicals from phosphate sources is described.

The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.