Provided is a method of preparing sulfonated aryl phosphine, the method capable of preparing sulfonated aryl phosphine with high purity and high yield by efficiently removing sulfur trioxide generated during preparing sulfonated aryl phosphine using an extractant.

The invention relates to a method for recovering an organic compound from a feed stream comprising the steps of extracting the organic compound into an organic solvent, thereby obtaining a mixture of the solvent and the organic compound; and simultaneously crystallizing the solvent and the organic compound by cooling the mixture; and separating the solid organic solvent and solid organic compound.

The present invention provides a stabilized form of Tetrofosmin, which is stable at room temperature as well as in contact with oxygen, and a non-radioactive kit containing a stabilized form of Tetrofosmin for the preparation of a radiopharmaceutical composition in the field of diagnostic radiopharmaceuticals, especially for myocardial perfusion studies in patients with coronary artery diseases and in oncology.

The invention relates to a method for recovering an organic compound from a feed stream comprising the steps ofextracting the organic compound into an organic solvent, thereby obtaining a mixture of the solvent and the organic compound; andsimultaneously crystallizing the solvent and the organic compound by cooling the mixture; and - separating the solid organic solvent and solid organic compound.

A method for preparing a phosphine compound using pyrophosphorous acid is provided. A phosphine oxide compound or a phosphine sulfide compound is reacted with reducing agent pyrophosphorous acid (H.sub.4P.sub.2O.sub.5) with or without impurities under stirring in the presence of a catalyst to produce a reaction product, where the catalyst is elementary halogen (X.sub.2) or halide (M.sub.XX.sub.Y). After the reaction is completed, the reaction product is subjected to water washing, extraction and purification to obtain the target phosphine compound.

A diphosphine precursor compounds of Formula (I), conjugates thereof of Formula (H) and radionuclide conjugate complexes thereof are disclosed herein. The compounds are advantageous at least because they enable the easy one-step extemporaneous preparation of the corresponding complexes in the clinic in high radiochemical yields and under mild conditions. Also disclosed are the methods of making the compounds and complexes herein along with their uses. The complexes are particularly useful in the field of medicine and diagnosis, such as in medical imaging and targeted payload delivery.

##STR00001##