Patent classifications
C07F9/6536
MACROCYCLIC PANTETHEINE DERIVATIVES AND USES THEREOF
The present disclosure relates to compounds of Formulae (I) or (II):
##STR00001##
and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.
MACROCYCLIC PANTETHEINE DERIVATIVES AND USES THEREOF
The present disclosure relates to compounds of Formulae (I) or (II):
##STR00001##
and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.
FUSED HETEROBICYCLIC ANTIVIRAL AGENTS
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof:
##STR00001##
which inhibit the cellular entry of hepatitis B virus (HBV) and/or hepatitis D virus (HDV) or interfere with the function of the life cycle of HBV and/or HDV and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV and/or HDV infection. The invention also relates to methods of treating an HBV and/or HDV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
FUSED HETEROBICYCLIC ANTIVIRAL AGENTS
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof:
##STR00001##
which inhibit the cellular entry of hepatitis B virus (HBV) and/or hepatitis D virus (HDV) or interfere with the function of the life cycle of HBV and/or HDV and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV and/or HDV infection. The invention also relates to methods of treating an HBV and/or HDV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Complexes Of CU(I) As Antitumor Agents
The invention relates to a Cu(1) complex of Formula (I), wherein L is a ligand of Formula (II), wherein n1, n2, n3 are independently to each other, an integer from 0 to 1, A1, A2 and A3 are independently from each other,a phenyl optionally substituted with (C.sub.1-C.sub.3)alkoxy, (C.sub.1-C.sub.3)alkyl, F, formyl, carboxyl, sulphonyl hydroxyl, hydroxyl, methoxy(C.sub.1-C.sub.3)alkoxy oran heterocyclic ring selected from piperazinyl, morpholynyl, thiomorpholynyl, optionally substituted with (C.sub.1-C.sub.3)alkyl, where the heterocyclic ring is linked with the nitrogen atom to CH.sub.2 residue, with the proviso that when A1, A2 or A3 is optionally substituted phenyl, then n1, n2 or n3, respectively, is 0, and when A1, A2 or A3 is optionally substituted heterocyclic ring, then n1, n2 or n3, respectively, is 1, for use in the treatment of tumours.