A compound of formula (I)

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or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants

Bisphosphite ligands based on benzopinacol, and the use thereof in hydroformylation.

The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof. Formula (I):

##STR00001##

The present invention provides a non-aqueous electrolytic solution which can be handled industrially stably, and which allows for achieving a good durability performance, particularly, a good capacity retention rate during repeated charging and discharging, of an energy device typified by a non-aqueous electrolytic solution secondary battery. The non-aqueous electrolytic solution contains a compound(s) represented by the following general formula(e) (A1) and/or (A2). In formula (A1), X.sup.1 represents a halogen atom; each of R.sup.1, R.sup.2, R.sup.5 and R.sup.6 independently represents a hydrogen atom, a halogen atom, or a hydrocarbon group having 10 or less carbon atoms optionally substituted with a halogen atom; and each of R.sup.3 and R.sup.4 independently represents a halogen atom, or a hydrocarbon group having 10 or less carbon atoms optionally substituted with a halogen atom; wherein at least two of R.sup.1 to R.sup.6 may be bonded to each other to form a ring. In formula (A2), each of X.sup.2 and X.sup.3 independently represents a halogen atom; and each of R.sup.7 to R.sup.14 independently represents a hydrogen atom, a halogen atom, or a hydrocarbon group having 10 or less carbon atoms optionally substituted with a halogen atom; wherein at least two of R.sup.7 to R.sup.14 may be bonded to each other to form a ring.

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Diphosphites having an open and a closed 2,4-methylated outer unit and use thereof in hydroformylation.

The present invention relates to a cellular transport system for bringing a sulfonic acid construct which carries a cargo into a cell and releasing the cargo in the cell's cytoplasm, the cellular transport system comprising: (i) a sulfonate transporter located in the cytoplasm membrane of the cell wherein said sulfonate transporter is capable of transporting said sulfonic acid construct across the cytoplasm membrane into the cytoplasm; (ii) a γ-glutamyl transferase (GGT; EC 2.3.2.2) which is modified to be located in the cytoplasm of the cell, wherein said γ-glutamyl transferase is capable of hydrolyzing said sulfonic acid construct so as to release the cargo. Moreover, the present invention relates to the use of a cellular transport system for bringing a sulfonic acid construct which contains a cargo into a cell and releasing the cargo in the cell's cytoplasm. Further, the present invention relates to a γ-glutamyl transferase for hydrolyzing a sulfonic acid construct which contains a cargo.

Polyolefin compositions comprising i) a polyolefin, ii) one or more phosphorus—containing benzofuranone compounds and iii) one or more hindered amine light stabilizers are provided excellent protection against discoloration and enhanced thermal stability during melt processing as exhibited by improved retention of molecular weight and maintenance of polymer molecular architecture.

The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.

New diphosphites based on cis-butene-1,4-diol.

6,6′-([1,1′-Biphenyl]-2,3′,-diylbis)oxy))didibenzo[d,f][1,3,2]dioxaphosphepines and the use thereof in hydroformylation.