The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

An improved agent and treatment method for a broad variety of diseases in both animals and humans is disclosed. The agent is an inventive composition comprising a bacterial-based culture. Particularly, the inventive composition disclosed herein is an active molecule produced by a Gram-negative bacterial strain that is a member of the genus Brevundimonas. Consumption of the inventive composition by way of liquid or dry feed produces a broad range of health benefits and has proven effective in the prevention and treatment of disease. The bacterium of the disclosed composition selectively modulates Toll-like receptors (TLRs) for the prevention and treatment of disease such as coccidiosis. Specific actions include but are not limited to improvement of gut health, acceleration or enhancement of immune response using a natural immune modulator, and the promotion of animal growth.

The present disclosure describes methods of treating cellulosic materials with compositions that allow greater retention of inorganic particles on cellulosic substrates. The methods as disclosed provide combining saccharide fatty acid esters (SFAE) with such inorganic particles and applying such combinations on cellulosic materials to eliminate or reduce the use of retention aids or binders for filler in the paper making process. Compositions comprising such combinations of SFAE and inorganic particles are also disclosed.

The present disclosure describes methods of treating cellulosic materials with compositions that allow greater retention of inorganic particles on cellulosic substrates. The methods as disclosed provide combining saccharide fatty acid esters (SFAE) with such inorganic particles and applying such combinations on cellulosic materials to eliminate or reduce the use of retention aids or binders for filler in the paper making process. Compositions comprising such combinations of SFAE and inorganic particles are also disclosed.

A method for producing a sugar fatty acid ester characterized in that a fatty acid ester and a saccharide are subject to a transesterification reaction using a weakly basic ion exchanger having a pK.sub.b of 3 to 7 as a catalyst.

A method for producing a sugar fatty acid ester characterized in that a fatty acid ester and a saccharide are subject to a transesterification reaction using a weakly basic ion exchanger having a pK.sub.b of 3 to 7 as a catalyst.

The invention is a coating for agricultural products, which includes at least 10% of renewably sourced and biodegradable sugar esters. The invention is also a method of making a coated agricultural product, including the steps of providing a coating composition comprising at least 10% of a renewably sourced and biodegradable sugar ester, heating the coating composition to a temperature to reduce its viscosity to below about 100 cP, adding the coating composition to an agricultural product to form a mixture, and cooling the mixture to produce a coated agricultural product. The invention is also a method of reducing dust released from an agricultural product that includes the step of providing a coating composition comprising at least 10% of a renewable sourced and biodegradable sugar ester. Enough of the coating composition is added to the agricultural product to reduce the amount of dust released from the agricultural product by at least half. Finally, the invention is also a method of reducing caking in a granular agricultural product.

The invention is a coating for agricultural products, which includes at least 10% of renewably sourced and biodegradable sugar esters. The invention is also a method of making a coated agricultural product, including the steps of providing a coating composition comprising at least 10% of a renewably sourced and biodegradable sugar ester, heating the coating composition to a temperature to reduce its viscosity to below about 100 cP, adding the coating composition to an agricultural product to form a mixture, and cooling the mixture to produce a coated agricultural product. The invention is also a method of reducing dust released from an agricultural product that includes the step of providing a coating composition comprising at least 10% of a renewable sourced and biodegradable sugar ester. Enough of the coating composition is added to the agricultural product to reduce the amount of dust released from the agricultural product by at least half. Finally, the invention is also a method of reducing caking in a granular agricultural product.

The present invention relates to new synthetic molecules with agonist activity of human Toll-like Receptor 4 (TLR4), compositions comprising them and uses thereof for the treatment of diseases in which it is useful to induce or increase an immune response. The compounds have general formula (1), wherein R.sub.1 is a saturated C.sub.8-C.sub.16 aliphatic chain having a ═0 on C.sub.1, said chain being free from —OH substituents on C.sub.3, wherein R.sub.2 is a saturated C.sub.8-C.sub.16 aliphatic chain having a ═O on C.sub.1, said chain being free from —OH substituents on C.sub.3, wherein R.sub.3 is a saturated C.sub.8-C.sub.16 aliphatic chain having a ═O on C.sub.1, said chain being free from —OH substituents on C.sub.3; wherein R.sub.4 is a hydrogen atom (H) or a phosphate group (PO.sub.4.sup.2−).

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