Provided are novel imidazopyrazine derivatives having the general formula (I), wherein R.sup.1 to R.sup.11 are as described herein

##STR00001##

and pharmaceutically acceptable salts thereof.

Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.

Provided are novel imidazopyrazine derivatives having the general formula (I), wherein R.sup.1 to R.sup.11 are as described herein

##STR00001##

and pharmaceutically acceptable salts thereof.

Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.

A compound of formula I: ##STR00001## or a salt thereof, wherein: R.sup.1 is —OC(H)(X)(CH.sub.2).sub.nC(═O)OH; R.sup.2 is —OH, —N.sub.3, or —N(H)C(═O)CH.sub.3; or R.sup.1 and R.sup.2 together with the carbon atoms to which they are attached form ##STR00002## R.sup.3 is —H, —CH.sub.3, —CH.sub.2C(═O)OH, or —CH.sub.2OH; X is —H, —CH.sub.3, —CH.sub.2OH, or CH.sub.2C(═O)OH; and n is 0 or 1.

A compound of formula I: ##STR00001## or a salt thereof, wherein: R.sup.1 is —OC(H)(X)(CH.sub.2).sub.nC(═O)OH; R.sup.2 is —OH, —N.sub.3, or —N(H)C(═O)CH.sub.3; or R.sup.1 and R.sup.2 together with the carbon atoms to which they are attached form ##STR00002## R.sup.3 is —H, —CH.sub.3, —CH.sub.2C(═O)OH, or —CH.sub.2OH; X is —H, —CH.sub.3, —CH.sub.2OH, or CH.sub.2C(═O)OH; and n is 0 or 1.

The present disclosure describes methods of preparing carbanucleosides.

The present disclosure describes methods of preparing carbanucleosides.

The present disclosure describes methods of preparing carbanucleosides.

The present disclosure describes methods of preparing carbanucleosides.

The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I):

##STR00001##

which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

The invention provides compounds of formula (I) with substituents as specified in claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac. ##STR00001##