Provided are methods relating to compositions that include a CDP-camptothecin or camptothecin derivative conjugate, e.g., CRLX101.

Disclosed herein are compositions of a deep eutectic solvent with a host, such as a supramolecular host, and the use of the composition to form a composition comprising the host in complex with one or more guests. The deep eutectic solvent provides an alternative medium to the aqueous-based media that have been used in the art to date. Also disclosed are compositions of a deep eutectic solvent with a redox-active compound, such as a viologen compound, and the use of the composition, for example, in a smart window or for agricultural use, such as in an agricultural product.

A method of promoting increased cellular hydration in a multicellular organism that is capable of intracellular water permeation includes the step of causing the multicellular organism to ingest an aqueous solution that contains an amount of a carbohydrate clathrate component. There is also a step of enhancing the intracellular permeation. The multicellular organism contains aquaporins, and the causing step involves interaction of the composition with the aquaporins. The cellular hydration promoted and caused by the method is corroborated by a test that uses human-aquaporin-expressed frog oocytes. The test uses single cell Xenopus laevis frog oocytes having expressed human aquaporin AGP1 water channels. There is also a beverage composition that increases lifespan in the multicellular organism, and a beverage composition that promotes cellular hydration when ingested by a multicellular organism.

The present invention relates to a sweetening composition comprising neohesperidin dihydrochalcone (NHDC) and gamma-cyclodextrin, to the use of the sweetening composition for sweetening ingestible products, namely, food products and pharmaceuticals, and to an ingestible product comprising the sweetening composition. Furthermore, the present invention also relates to the use of a composition comprising neohesperidin dihydrochalcone and a cyclodextrin selected from beta-cyclodextrin and gamma-cyclodextrin as taste-masking agent, to a process for masking unpleasant tastes in ingestible products, namely in food products and pharmaceuticals, and to ingestible products which comprise unpleasantly tasting substances and the taste-masking composition.

A clathrate of 1-methylcyclopropene with α-cyclodextrin, obtained as a solid particulate product, is modified by comminuting, classifying, or both to obtain a modified particulate. When subjected to identical atmospheric disgorgement conditions of humidity and temperature, identical masses of the modified and unmodified particulates exhibit different rates of 1-methylcyclopropene disgorgement. Specifically, we have found that a smaller mean particle size is inversely related to a greater rate of 1-methylcyclopropene release.

The present invention relates to a sweetening composition comprising neohesperidin dihydrochalcone (NHDC) and gamma-cyclodextrin, to the use of the sweetening composition for sweetening ingestible products, namely, food products and pharmaceuticals, and to an ingestible product comprising the sweetening composition. Furthermore, the present invention also relates to the use of a composition comprising neohesperidin dihydrochalcone and a cyclodextrin selected from beta-cyclodextrin and gamma-cyclodextrin as taste-masking agent, to a process for masking unpleasant tastes in ingestible products, namely in food products and pharmaceuticals, and to ingestible products which comprise unpleasantly tasting substances and the taste-masking composition.

Particles using a polymer having a particle size suitable for a drug delivery system (DDS) or the like are provided. A drug and an anti-cancer agent using the particles are provided. Each of the particles comprises a polymer having a structure unit derived from a saccharide compound having a hydroxyl group and having an inclusion property and a structure unit derived from a monomer having a functional group to be reacted with a hydroxyl group, and has the average hydrodynamic radius (R.sub.hav) of 5 to 100 nm. A method for producing the particles comprises a step of mixing a mixed composition comprising a saccharide compound, a monomer, a surfactant, and an alkaline aqueous solution having a pH of 12 or more. A drug compress a hydrophobic physiological active agent, such as α-mangostin contained in the particle, and an anti-cancer agent comprising the drug.

An electrophotographic photosensitive member, which is suppressed in occurrence of fogging and is excellent in abrasion resistance. In the electrophotographic photosensitive member, an outermost surface layer of the electrophotographic photosensitive member comprises a polymerized product of a composition comprising at least a polyrotaxane and a monomer having a polymerizable reactive group, and a chain molecule of the polyrotaxane has two blocking groups at both terminals thereof, and a (meth)acryloyloxy group of a cyclic molecule of the polyrotaxane forms a bond.

The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.

The present invention provides a polyimide composite having a structural formula of PI/Fe.sub.3O.sub.4-(β-CD-Ada)x, wherein x=3-5. One aspect of the invention provides a polyimide composite. By introducing Fe.sub.3O.sub.4 as a host material of an electromagnetic wave absorption material and introducing a guest material, a repairing property of the material itself is imparted by an interaction between the host material and the guest material. Therefore, the polyimide composite has an electromagnetic radiation shielding property and a self-repairing property.