The invention relates to a poly[α-cyanoacrylate] hydrolyzate, a preparation method and an application thereof, belonging to the field of pharmaceutical and chemical industry. A main technical solution is as follows: provided is a poly[α-cyanoacrylate] hydrolyzate having a chemical formula: CH.sub.2—CRCOOH.sub.n, wherein R=—CN or —COOH. Poly[2-cyanoacrylic acid] provided by the present invention is dispersed in water to prepare the negatively charged microsphere, that is, to obtain the new blank embolic microsphere, the particle size of the microsphere can be adjusted in a micron-scale range, and the microsphere have a deformation function to pass through a vascular with a specific shape, which can tightly embolize the vascular to avoid ectopic embolism caused by falling off; poly[2-carboxyacrylic acid] can be used for preparing a new nano-drug carrier, improving the curative effect of the carried drug on diseased tissues and reduce the toxic and side effects of the carried drug on normal tissues.

The invention relates to a poly[α-cyanoacrylate] hydrolyzate, a preparation method and an application thereof, belonging to the field of pharmaceutical and chemical industry. A main technical solution is as follows: provided is a poly[α-cyanoacrylate] hydrolyzate having a chemical formula: CH.sub.2—CRCOOH.sub.n, wherein R=—CN or —COOH. Poly[2-cyanoacrylic acid] provided by the present invention is dispersed in water to prepare the negatively charged microsphere, that is, to obtain the new blank embolic microsphere, the particle size of the microsphere can be adjusted in a micron-scale range, and the microsphere have a deformation function to pass through a vascular with a specific shape, which can tightly embolize the vascular to avoid ectopic embolism caused by falling off; poly[2-carboxyacrylic acid] can be used for preparing a new nano-drug carrier, improving the curative effect of the carried drug on diseased tissues and reduce the toxic and side effects of the carried drug on normal tissues.

The present invention relates to nanoparticles based on optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity, a method for preparing such nanoparticles, compositions comprising such nanoparticles and medical uses thereof. The invention further relates to the use of optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity for preparing nanoparticles as well as to a method for preparing such polymers.

The present invention relates to nanoparticles based on optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity, a method for preparing such nanoparticles, compositions comprising such nanoparticles and medical uses thereof. The invention further relates to the use of optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity for preparing nanoparticles as well as to a method for preparing such polymers.

The present invention relates to nanoparticles based on optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity, a method for preparing such nanoparticles, compositions comprising such nanoparticles and medical uses thereof. The invention further relates to the use of optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity for preparing nanoparticles as well as to a method for preparing such polymers.

The present invention relates to nanoparticles based on optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity, a method for preparing such nanoparticles, compositions comprising such nanoparticles and medical uses thereof. The invention further relates to the use of optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity for preparing nanoparticles as well as to a method for preparing such polymers.