The invention relates to a nanoparticle comprising copolymeric or homopolymeric compounds which comprise cyanoacrylate subunits according to formula 2A, wherein each R.sup.1 is independently selected from the group consisting of 2-ethylhexyl, 2-phenylethyl, neopentyl, 1-pentyl, 2-pentyl, 3-pentyl, 3,3-dimethyl-1-butyl, 3-methylbutyl, -heptyl, 2-heptyl, and 3-heptyl; and wherein the nanoparticle further comprises an active agent. The invention also provides compositions comprising the nanoparticles, and the nanoparticles for use in therapy or diagnosis, such as in the treatment of cancer or an infection, or for use in diagnostic imaging.

The invention relates to a nanoparticle comprising copolymeric or homopolymeric compounds which comprise cyanoacrylate subunits according to formula 2A, wherein each R.sup.1 is independently selected from the group consisting of 2-ethylhexyl, 2-phenylethyl, neopentyl, 1-pentyl, 2-pentyl, 3-pentyl, 3,3-dimethyl-1-butyl, 3-methylbutyl, -heptyl, 2-heptyl, and 3-heptyl; and wherein the nanoparticle further comprises an active agent. The invention also provides compositions comprising the nanoparticles, and the nanoparticles for use in therapy or diagnosis, such as in the treatment of cancer or an infection, or for use in diagnostic imaging.

The present invention relates to a curable composition comprising a curable cyanoacrylate component and at least one thermoplastic polyurethane (TPU) component. The compositions of the invention are non-flowable at room temperature (25° C.) and are suitable for use as adhesive compositions, for example in a tape form.

The present invention relates to a curable composition comprising a curable cyanoacrylate component and at least one thermoplastic polyurethane (TPU) component. The compositions of the invention are non-flowable at room temperature (25° C.) and are suitable for use as adhesive compositions, for example in a tape form.

This invention relates to cyanoacrylate-containing compositions that include (a) a beta-alkoxy cyanoacrylate component, (b) a cyanoacrylate component selected from butyl cyanoacrylates, octyl cyanoacrylates, and combinations thereof; (c) a rubber toughening component (d) a surface modified component; and (e) an adhesion promoter. Cured products of the inventive cyanoacrylate compositions demonstrate improved toughness without an odor typically found with cyanoacrylate-containing compositions.

This invention relates to cyanoacrylate-containing compositions that include (a) a beta-alkoxy cyanoacrylate component, (b) a cyanoacrylate component selected from butyl cyanoacrylates, octyl cyanoacrylates, and combinations thereof; (c) a rubber toughening component (d) a surface modified component; and (e) an adhesion promoter. Cured products of the inventive cyanoacrylate compositions demonstrate improved toughness without an odor typically found with cyanoacrylate-containing compositions.

Provided herein are therapeutic acrylate compounds useful as medical adhesives, comprising a therapeutic agent covalently linked to a methacrylate or cyanoacrylate moiety. Adhesive compositions and kits, such as liquid sutures and bone cement also are provided along with uses for the compositions.

A process for the preparation of targeting nanoparticles of a poly(alkyl cyanoacrylate) homopolymer or copolymer, wherein said method comprises, in a single step, the anionic polymerisation of an oil-in-water miniemulsion as herein defined. The invention also relates to nanoparticles produced from said process and to their use in medicine.

A process for the preparation of targeting nanoparticles of a poly(alkyl cyanoacrylate) homopolymer or copolymer, wherein said method comprises, in a single step, the anionic polymerisation of an oil-in-water miniemulsion as herein defined. The invention also relates to nanoparticles produced from said process and to their use in medicine.

This invention relates to cyanoacrylate-containing compositions that include (a) a beta-alkoxy cyanoacrylate component, (b) a cyanoacrylate component selected from butyl cyanoacrylates, octyl cyanoacrylates, and combinations thereof; (c) a rubber toughening component (d) a surface modified component; and (e) an adhesion promoter. Cured products of the inventive cyanoacrylate compositions demonstrate improved toughness without an odor typically found with cyanoacrylate-containing compositions.