Disclosed is a modified biopolymer having the formula A-XY wherein: (a) A is a starting material selected from the group consisting of a polysaccharide, a protein and a cellulose; (b) X is a first moiety bearing a functionality co-reactive with A; (c) Y is a second moiety covalently bound to X, capable of undergoing free radical polymerization and bearing at least two ethylenically unsaturated functional groups; (d) the starting material A and the first moiety X are linked covalently through linkages selected from the group consisting of an ester, an amide, a urethane, a urea, a sulfonate ester, a phosphate ester and an ether; and (e) a degree of substitution of the starting material A with the first moiety X is less than 0.5 but more than 0.1. Compositions including the modified biopolymer and methods for making them are also disclosed.

Disclosed is a modified biopolymer having the formula A-XY wherein: (a) A is a starting material selected from the group consisting of a polysaccharide, a protein and a cellulose; (b) X is a first moiety bearing a functionality co-reactive with A; (c) Y is a second moiety covalently bound to X, capable of undergoing free radical polymerization and bearing at least two ethylenically unsaturated functional groups; (d) the starting material A and the first moiety X are linked covalently through linkages selected from the group consisting of an ester, an amide, a urethane, a urea, a sulfonate ester, a phosphate ester and an ether; and (e) a degree of substitution of the starting material A with the first moiety X is less than 0.5 but more than 0.1. Compositions including the modified biopolymer and methods for making them are also disclosed.

In an example, a material includes a cellulosic nanomaterial and multiple polymer chains chemically bonded to the cellulosic nanomaterial. Each polymer chain includes a styrene-butadiene copolymer.

In an example, a material includes a cellulosic nanomaterial and multiple polymer chains chemically bonded to the cellulosic nanomaterial. Each polymer chain includes a styrene-butadiene copolymer.

Provided are a macromolecular material excellent in mechanical strength and a production method therefor. A macromolecular material of the present invention has a structure crosslinked through host-guest interaction, and is obtained by a method including: a step of preparing a mixture of a host-group-containing macromolecular compound swollen or dissolved in a solvent and a guest-group-containing macromolecular compound swollen or dissolved in a solvent; and a step of mechanically kneading the mixture. As another aspect, a macromolecular material of the present invention is obtained by a method including: a step of swelling or dissolving a both host-group- and guest-group-containing macromolecular compound in a solvent; and a step of mechanically kneading the swollen or dissolved macromolecular compound.

Biocompatible copolymers and thermo-responsive hydrogels formed from the copolymers are disclosed. The biocompatible copolymers include monomers comprising polysaccharides or derivatives thereof, therapeutic agents or derivatives thereof and thermo-responsive monomers and are cross-linked with an acrylamide-containing crosslinker. The hydrogels are used as implant materials to treat or prevent joint damage or osteoarthritis in a subject.

Biocompatible copolymers and thermo-responsive hydrogels formed from the copolymers are disclosed. The biocompatible copolymers include monomers comprising polysaccharides or derivatives thereof, therapeutic agents or derivatives thereof and thermo-responsive monomers and are cross-linked with an acrylamide-containing crosslinker. The hydrogels are used as implant materials to treat or prevent joint damage or osteoarthritis in a subject.

Biocompatible copolymers and thermo-responsive hydrogels formed from the copolymers are disclosed. The biocompatible copolymers include monomers comprising polysaccharides or derivatives thereof, therapeutic agents or derivatives thereof and thermo-responsive monomers and are cross-linked with an acrylamide-containing crosslinker. The hydrogels are used as implant materials to treat or prevent joint damage or osteoarthritis in a subject.

Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.

Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.