Methods of forming, dissolving, and functionalizing an extracellular matrix gel on demand based on cross-linking, modification, and dissolution of hydrogels using transpeptidase (e.g. sortase) are disclosed. Also provided are hydrogels comprising one or more macromers crosslinked to a mixture of peptides, wherein all or a portion of the peptides in the mixture comprise a recognition motif cleavable by a transpeptidase (e.g., sortase).

The present invention provides a polyethylene glycol derivative comprising a repeat unit having the structure of Formula (I) and a terminal group having the structure of Formula (II). The polyethylene glycol derivative provided by the present invention has good biocompatibility, due to the repeat unit having the structure of Formula (I); and can react with various groups such as amino, (acyl)hydrazino, and aminooxy with a fast reaction rate under mild reaction conditions, due to the o-phthalaldehyde terminal group having the structure of Formula (II). The polyethylene glycol derivative provided by the present invention is mixed with polyethylene glycol having an amino-containing terminal group in an aqueous medium, to rapidly form a chemically cross-linked hydrogel material. The hydrogel material has mild preparation conditions, fast gel-forming speed, high mechanical strength, and good stability. This polyethylene glycol hydrogel can be applied as drug sustained-release carrier, tissue engineering scaffold, etc. in the field of biomedical materials.

A capped poly(arylene ether) copolymer includes a reactive end group, wherein the capped poly(arylene ether) copolymer is derived from an alkyl, aryl-phenol.

The present invention enables the achievement of a coating agent composition which contains a perfluoropolyether compound (A) of a specific structure, and dissolves into at least one volatile organic solvent that does not contain a fluorine atom without using a fluorine-containing solvent having a boiling point of 260° C. or less at atmospheric pressure by setting the content ratio of a non-functional perfluoropolyether compound (B) relative to a total of 100% by mole of the component (A) and the component (B) to less than 2.5% by mole, while forming a cured coating film by being rapidly cured on a base material, said cured coating film firmly adhering to the base material and exhibiting excellent water repellent oil repellent properties, sliding properties, mold releasability and the like.

A process for preparing silane-terminated polymers (SP) of the formula (I),

Y—[O—C(═O)—NH—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a].sub.x  (I),

includes in a 1.sup.st process step at least one polymer (OHP) of the formula (II),

Y—[OH].sub.x  (II),

being reacted with at least one isocyanate-functional silane (IS) of the formula (III),

O═C═N—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a  (III),

with the proviso that the isocyanate-functional silanes (IS) are used in an amount such that there are at least 1.05 isocyanate groups in the silanes (IS) to each hydroxyl group in the compounds (OHP). Subsequently, in a 2.sup.nd process step, the unreacted isocyanate groups of the silanes (IS) are reacted, in the reaction mixture obtained in the 1.sup.st process step, with at least one alcohol (A) of the formula (IV),

R.sup.3OH  (IV)

Subsequently, in a 3.sup.rd process step, the reaction mixture obtained in the 2.sup.nd process step is passed through an evaporation unit (VD).

Provided are a photocurable fluoropolyether-based elastomer composition having both a favorable preservation stability and fast curability, being bondable at a low temperature in a short period of time, and generating no air bubbles in the resin at the time of curing; and a bonding method thereof. The photocurable fluoropolyether-based elastomer composition contains: (A) a linear polyfluoro compound; (B) a fluorine-containing organohydrogenpolysiloxane; (C) a photoactive hydrosilylation reaction catalyst; and (D) a zeolite having an average primary particle size of not larger than 30 μm.

A substantially biobased prepolymer mixture including 31.80 to 67.95 percent biogenic carbon content by weight, wherein the mixture is a combination of: an isocyanate; and a cleaned biobased polyoxyalkylene glycol polyol, wherein the cleaned biobased polyoxyalkylene glycol polyol is completely primary hydroxyl-tipped or primary hydroxyl end-grouped, further wherein said cleaned biobased polyoxyalkylene glycol polyol is polymerized from 100% biobased ethylene oxide, further wherein the cleaned biobased polyoxyalkylene glycol polyol comprises less than 15 ppm sodium and potassium metals, and further wherein the cleaned biobased polyoxyalkylene glycol polyol comprises less than 0.5% water by weight.

A fluorine-containing ether compound represented by the following formula (1).

R.sup.1—R.sup.2—CH.sub.2—R.sup.3—CH.sub.2—R.sup.4  (1)

(R.sup.1 is an organic group having an alicyclic structure having 3 to 13 carbon atoms; R.sup.2 is represented by the following formula (2), and a in the formula (2) is an integer of 1 to 3; R.sup.3 is a perfluoropolyether chain; and R.sup.4 is a terminal group having two or three polar groups, in which individual polar groups bond to different carbon atoms and the carbon atoms to which the polar groups bond are bonded to each other through a linking group having a carbon atom to which the polar groups do not bond.)

##STR00001##

A polyphenylene ether resin modified with benzoxazine, a method for producing the same, and a substrate material for a circuit board are provided. The polyphenylene ether resin modified with the benzoxazine has a structural formula as follows:

##STR00001## in which R represents a chemical group that is located between two hydroxyphenyl functional groups of a bisphenol compound, and n is an integer between 3 and 25, inclusive.

A polyphenylene ether bismaleimide resin, a method for manufacturing the same, and a resin composition are provided. The polyphenylene ether bismaleimide (PPE-BMI) resin is obtained by a condensation reaction with a maleic anhydride and a primary amine compound as reactants. The primary amine compound is a polyphenylene ether diamine.