Described herein are substituted polyetheramines with a low melting point which are obtainable by condensation of at least two N-(hydroxyalkyl)amines to obtain a polyetheramine and subsequent reaction of at least one remaining hydroxy group and/or, if present, at least one secondary amino group of said polyetheramine with ethylene oxide and at least one further alkylene oxide to obtain a substituted polyetheramine. Uses of such substituted polyetheramines in fields of cosmetic formulations, as crude oil emulsion brakers, in pigment dispersions of ink jets, in electro paintings, or in cementitious compositions as well as methods wherein said substituted polyetheramines are used in said fields are described herein.

It is provided a method of treatment of a human or animal patient in need thereof to achieve a reduction of the viscosity of mucus of the patient which is carried out by administering a polyglycerol derivative having a linear or dendritic polyglycerol backbone and carrying at least one thiol group covalently bound to the polyglycerol backbone. It is further provided a method of treatment of a human or animal patient suffering from chronic sinusitis, asthma, chronic bronchitis, cystic fibrosis, chronic obstructive pulmonary disease, emphysema, bronchiectasis, chronic inflammatory bowel diseases, constipation, gastrointestinal malabsorption syndrome, irritable bowel syndrome, steatorrhea or diarrhea by administering a polyglycerol derivative. Further specific thiol-functionalized polyglycerol derivatives and a corresponding manufacturing method are provided.

Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.

The invention relates to a hyperbranched polymer comprising:

a) a hyperbranched polycondensate with hydroxyl end groups, amino end groups, or a combination thereof condensed to
b) one or more linking groups connected to
c1) one or more polyethylene glycol monomethyl ethers and
c2) one or more poly(C.sub.2-C.sub.3)alkylene glycol mono-(C.sub.8-C.sub.22)-alkyl ethers,
wherein the weight ratio of components c1):c2) is from 9:1 to 1:9. It further relates to a process for producing the polymer, to a composition comprising the polymer and an active ingredient, and to a method for controlling phytopathogenic fungi or undesired vegetation or insect or acarid infestations or for regulating the growth of plants.

The present invention relates to amphiphilic star-like polyether. The core molecule is an aliphatic hyperbranched polyether polyol, which is further alkoxylated, first with ethylene oxide or combinations of ethylene oxide and C.sub.3-C.sub.20 alkylene oxide, preferably propylene oxide, and/or glycidol, and then with a C.sub.3-C.sub.20 alkylene oxide, preferably propylene oxide, or combination of ethylene oxide and propylene oxide, then optionally anionically modified. The resulting amphiphilic star-like polyether thus has an inner core based on an aliphatic hyperbranched polyether polyol, an inner shell predominantly containing polyethylene oxide units, the inner shell comprising at least 3 ethylene oxide units and an outer shell predominantly containing polypropylene oxide units, the outer shell comprising at least 3 propylene oxide units. They optionally contain anionic groups instead of hydroxyl groups on the periphery of the macromolecule. The invention further relates to their use as additive in laundry formulations and to their manufacturing process.

The invention provides polyglycerol alkoxylate esters and for the preparation and use thereof.

In various embodiments a polyrotaxane carrier for in vivo delivery of a nucleic acid is provided. In certain embodiments the carrier comprises: a multi-arm polyethylene glycol (PEG) backbone comprising at least three arms; at least one cyclic compound having a cavity, where an arm of said multi-arm PEG backbone is threaded into the cavity of said cyclic compound forming an inclusion complex; a bulky moiety capping the terminal of the arm(s) threaded into said cyclic compound where said moiety inhibits dethreading of the cyclodextrin from the arm(s) of said backbone; and where at least one arm of said PEG backbone is free of cyclic compounds; and where said carrier has a net positive charge.

Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.

The present invention provides a composition comprising branched polyglycerol for controlling freezing, more specifically, the composition has a number average molecular weight of 1,000 to 20,000 g/mol and a branching of 0.1 to 1, and may control enhancement or inhibition of ice recrystallization by adjusting a content of polyglycerol.

The present invention provides a composition comprising branched polyglycerol for controlling freezing, more specifically, the composition has a number average molecular weight of 1,000 to 20,000 g/mol and a branching of 0.1 to 1, and may control enhancement or inhibition of ice recrystallization by adjusting a content of polyglycerol.