Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.

A polymer composition comprising a star-branched copolymer having a plurality of arms is disclosed. Each polymer arm has a molecular weight Mp of from 1 kg/mol to 50 kg/mol and comprises polymerized units (i) derived from a first vinyl aromatic monomer comprising a radical-reactive group, wherein from greater than 10 mol % to 100 mol % of the units (i) are unhydrogenated; and optionally, polymerized units (ii) comprising hydrogenated and unhydrogenated forms of polymerized units derived from a high Tg monomer, and hydrogenated form of polymerized units (i) or hydrogenated form of polymerized styrene units; and optionally, polymerized units (iii) comprising (a) hydrogenated form of polymerized units derived from one or more acyclic conjugated dienes, and (b) polymerized units derived from one or more of a second vinyl aromatic monomer; wherein less than 10 wt. % of units (a) are unhydrogenated.

Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.

In an additive for an epoxy adhesive and an epoxy adhesive composition for construction including same, the additive for an epoxy adhesive is formed by atomic transfer radical polymerization (ATRP) of a polyacrylate of which one terminal is halogenated, as an arm-polymer, and a diacrylate-based compound or a dimethacrylate-based compound, as a cross-linker, and comprises a star polymer of a star-shape having a core/shell structure including a core formed by the polymerization of the cross-linker and a shell formed by a portion of the arm-polymer.

Polymer compositions comprising stiff and tough star shaped styrene butadiene block-copolymers A1 and A2 can be used for making shrink films. Block copolymer A2 preferably has the structure

##STR00001##

with hard blocks S.sub.e and S.sub.i, hard random copolymer blocks (B/S).sub.Ae, soft random copolymer blocks (B/S).sub.B coupled by a coupling agent X.

Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least two component polymers, a first polymer including an aminooxy group and a second polymer including a reactive oxo group, that are cross-linked by oxime bonds. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.

The present invention relates to multi-arm salt-tolerant star macromolecules, and methods of preparing and using the same. In one aspect of the invention, a salt-tolerant star macromolecule is capable of providing salt-tolerance to an aqueous composition.

Polymer blend comprising 95 to 100% of a component A) and 0 to 5% of additives, where A) is consisting of polymers A1 ) to A4): A1 ) 50 to 75% of a star shaped block copolymer A1 which comprises at least 2 terminal vinylaromatic hard blocks S and diene soft blocks B, where the proportion of the hard blocks S is from 65 to 90%, and Mn of block S is 35000 to 200000; A2) 5 to 15% of block copolymer A2 which comprises 2 terminal vinylaromatic hard blocks S1 and S2 and random copolymer blocks (B/S) consisting of 20 to 60% vinylaromatic monomers, and 80 to 40% dienes where the proportion of blocks S1 and S2 is 40 to 60%; and Mn of blocks S1 is 35000 to 200000, and Mn of blocks S2 is 5000 to 30000 and the molar S1/S2 ratio is 1:0.5 to 1:10; A3) 3 to 10% of an block copolymer A3 built up from vinylaromatic hard blocks S and from random soft blocks B/S consisting of 60 to 30% vinylaromatic monomers and 40 to 70% dienes, where the diene content is less than 50% and the proportion of the soft phase is at least 60%; and A4) 10 to 35% polystyrene A4; whereby the ratio of A1 ) to A2) to A3) is from 7 : [1.2 to 1.9] : [0.5 to 12], have particular mechanical properties.

Hydrogels are based on the reaction of thiols with electron-deficient heteroaromatics. This reaction can take place under physiological conditions and is thus suitable for the encapsulation of cells.

The present invention relates to multi-arm salt-tolerant star macromolecules, and methods of preparing and using the same. In one aspect of the invention, a salt-tolerant star macromolecule is capable of providing salt-tolerance to an aqueous composition.