A biomedical device is disclosed. The biomedical device includes a polymerization product of a biomedical device-forming mixture containing (a) one or more grafted glycosaminoglycan polymers including a glycosaminoglycan having a polymer backbone and one or more side chains comprising an ethylenically unsaturated reactive-containing residue grafted onto the polymer backbone, and (b) one or more non-silicone biomedical device-forming monomers.

A preparation method of a hydrogel of a mercapto-modified macromolecular compound includes the steps of combining the mercapto-modified macromolecular compound with an acrylated macromolecular compound and/or an acrylated micromolecular crosslinker. The mercapto-modified macromolecular compound can be crosslinked with the acrylated macromolecular compound and/or the acrylated micromolecular crosslinker under physiological conditions to form the hydrogel. Due to the rapid mercapto-vinyl crosslinking reaction, the formed hydrogel system can be quickly gelled in situ after being injected into the body. The hydrogel is thus suitable for use in the fields of biomedicine, medical cosmetic plastic surgery and cosmetics.

A cellulose nanofiber (CNF) powder of the present invention contains cellulose nanofibers, and a hydrophobic polymer that is chemically bonded to at least some of the —OH groups of the cellulose nanofibers. The CNF powder has the ability to be dispersed in water and to return to a powder form again when an aqueous dispersion of the CNF powder is dried. The distance between the fibers in the CNF powder in a dry state is 3 nm or more, and preferably 8 to 12 nm. Since the distance between the fibers in the conventional cellulose nanofibers is about 1 nm, the present invention reduces the Van der Waals force between the fibers (i.e., the force of attraction between the fibers) to one millionth of that of the conventional cellulose nanofibers. Thus, the present invention provides the CNF powder that can be used in a powder form, and that can also be reversibly changed between a powder state and a dispersed state in water, and a method for producing the CNF powder.

This invention belongs to the technical field of composite materials, and discloses a xylan-based dual network nanocomposite hydrogel, preparation method thereof and use therefor. The method comprises (1) adding graphite oxide powder into deionized water, ultrasonically dispersing to obtain a GO aqueous dispersion; (2) adding xylan into deionized water, heating and stirring to obtain a xylan solution; (3) adding a water-soluble calcium salt, a reaction monomer and the xylan solution into the GO aqueous dispersion, and stirring and dispersing uniformly under an ice-bath condition, then adding an initiator, a crosslinking agent and an accelerator, stirring and mixing uniformly to obtain a mixed solution; and 4) drying and reacting the mixed solution (in the step (3) to obtain a xylan-based dual network nanocomposite hydrogel. The composite hydrogel obtained by this invention has high mechanical property, is biodegradable and biocompatible, and can be used in the field of biomedicine, such as tissue engineering, drug sustained release, cell culture scaffold and cartilage tissue, etc.

The present invention provides a bionic fiber adsorptive material with multi-adsorption sites and a preparation method and use thereof, and the material is rich in multi-adsorption sites (N, O and S). The material is obtained by blending three polyethyleneimine polymers modified by multifunctional groups respectively with a carboxylated nanocellulose and graphene oxide, then adopting a coaxial spinning method based on a principle of imitating spider spinning, and then adopting a post-crosslinking technology. The material has a multilayer structure with the nanocellulose as a skeleton, the graphene oxide as an outer layer, and the three polyethyleneimine polymers modified by the multifunctional groups respectively as an inner layer, and a connection among the layers is a chemical bond connection. Densities of N, O and S adsorption sites of the material according to the present invention are all higher than 5 mmol/g.

The present invention provides a bionic fiber adsorptive material with multi-adsorption sites and a preparation method and use thereof, and the material is rich in multi-adsorption sites (N, O and S). The material is obtained by blending three polyethyleneimine polymers modified by multifunctional groups respectively with a carboxylated nanocellulose and graphene oxide, then adopting a coaxial spinning method based on a principle of imitating spider spinning, and then adopting a post-crosslinking technology. The material has a multilayer structure with the nanocellulose as a skeleton, the graphene oxide as an outer layer, and the three polyethyleneimine polymers modified by the multifunctional groups respectively as an inner layer, and a connection among the layers is a chemical bond connection. Densities of N, O and S adsorption sites of the material according to the present invention are all higher than 5 mmol/g.

The present invention belongs to the technical field of composite materials, and disclosed are a xylan-based double network nanocomposite hydrogel and the preparation and application thereof. The method includes: (1) adding a graphite oxide powder into deionized water, and ultrasonically dispersing to obtain a GO water dispersion; (2) adding xylan into deionized water, heating and stiffing to obtain a xylan solution; (3) adding a water-soluble calcium salt, a reaction monomer and the xylan solution into the GO water dispersion, stiffing and dispersing uniformly under an ice-bath condition, adding an initiator, a cross-linking agent and an accelerator, and stiffing to mix well so as to obtain a mixed solution; (4) subjecting the mixed solution of step (3) to a drying reaction, to obtain the xylan based double network nanocomposite hydrogel. The composite hydrogel obtained in the present invention has high mechanical properties, is biodegradable and has good biocompatibility. The present invention is applicable in the field of biomedicine, such as tissue engineering, drug sustained-release, cell culture scaffold and cartilage tissue, etc.

The invention relates to a drug delivery device adapted for carrying and delivering both hydrophilic and lipophilic drug molecules. The drug delivery device includes a porous body for adsorption of drug molecules, the body including a plurality of microspheres, and a hydrogel forming cross-links connecting the plurality of microspheres.

A method for preparing anisotropic cellulose-based hydrogel is provided. The method comprises ammoniating the dialdehyde cellulose obtained by oxidizing cellulose using sodium periodate to obtain ammoniated cellulose derivatives; performing Schiff reaction using the ammoniated cellulose derivatives and dopamine to obtain cellulose-based nanosheets; depositing Fe.sub.3O.sub.4 nanoparticles on a surface of the cellulose-based nanosheets by a deposition method to obtain magnetic cellulose-based nanosheets; and forming the anisotropic cellulose-based hydrogel using the magnetic cellulose-based nanosheets by a polymerization method.

Using an organic compound having a bottle brush structure, a material having softness and resilience and having excellent low-friction performance (SRT material) can be provided. Preferably, the SRT material contains a reinforcing filler, and may contain a lubricating liquid to be gelled.