The present disclosure relates to thermoplastic collagen elastomer compositions comprising collagen, at least one reactive thermoplastic elastomer, and at least one softener, as well as composite materials made from these compositions. Methods of making and using the thermoplastic collagen elastomer composite materials to produce engineered leather are also disclosed.

A preparation method of a hydrogel of a mercapto-modified macromolecular compound includes the steps of combining the mercapto-modified macromolecular compound with an acrylated macromolecular compound and/or an acrylated micromolecular crosslinker. The mercapto-modified macromolecular compound can be crosslinked with the acrylated macromolecular compound and/or the acrylated micromolecular crosslinker under physiological conditions to form the hydrogel. Due to the rapid mercapto-vinyl crosslinking reaction, the formed hydrogel system can be quickly gelled in situ after being injected into the body. The hydrogel is thus suitable for use in the fields of biomedicine, medical cosmetic plastic surgery and cosmetics.

Pitch granules including a core made up of a first composition including at least one pitch, the composition having a penetrability at 25° C. of 0 to 45 1/10 mm, a ring-and-ball softening temperature (TBA) of 55° C. to 175° C., understanding the penetrability as measured according to standard EN 1426 and the TBA as measured according to standard EN 1427, and a layer encapsulating at least one portion of the surface of the core, the layer being made up of a coating composition including at least one anti-caking agent.

A composition includes a cartilage component for regeneration of cartilage and a manufacturing method therefor. A composition for regeneration of cartilage, in which a micronized cartilage powder is physically mixed with a biocompatible polymer or a chemically crosslinked biocompatible polymer. When applied, the composition can increase morphological retention and ease of use at cartilage injury sites.

Filter made entirely with natural and biodegradable materials, for the protection of the respiratory tract of patients in the medical-surgical field and process for making it. The filter has a porosity or 80-98% and pore diameters of 100-350 micrometers and the pores have a shape of channels open at the ends, which are parallel to each other. The filter is obtained by preparing an aqueous solution of chitosan and an aqueous solution of gelatin, mixing them, pouring it into a container, keeping the container closed until obtaining a hydrogel and freeze-drying. A cross-linking step takes place by (a) adding a chemical cross-linker to the mixture of the chitosan and gelatine solutions and cross-linking before freeze-drying, or (b) subjecting the freeze-drying product to a thermal dehydration treatment.

According to the present disclosure, a method of preparing polymeric microparticles comprising further crosslinking with an organic crosslinking agent after crosslinking with metal ions, polymeric microparticles, medical compositions, cosmetic compositions, medical articles and cosmetic articles comprising the same can be provided.

The present disclosure can provide a gel precursor, a nucleic acid amplification reagent gel, a storage chip and a using method thereof. The gel precursor includes: a sodium alginate main solution mixed with at least one of the following components: starch, dextrin, chitosan, agarose and gelatin, where the sodium alginate main solution has a mass concentration range from 0.01% w/v to 5% w/v.

The present invention relates to a method for preparing a surgical anti-adhesion barrier film comprising the following steps: a°) a first solution, comprising an oxidized collagen is prepared, b) a polyphosphate compound is added to the solution of a) in a quantity so as to obtain a concentration of polyphosphate ranging from 0.007 to 0.7%, by weight, with respect to the total weight of the solution, c) the pH of the solution obtained in b) is adjusted to about 9 by addition of a base or to about 5.1 by addition of an acid, d) a diluted solution is prepared by adding water to solution of c), e) a first layer of solution obtained in c) is casted on an inert support, f) before complete gelation of the layer obtained in d), a second layer, of diluted solution obtained in d) is applied on top of said first layer and let to gelify, g) the gelified first and second layers are dried to obtain a film. The invention further relates to a film obtainable by such a method and to a surgical implant comprising a prosthetic fabric and such a film.

A bioprintable material is provided. The bioprintable material includes a hydrogel and microfilaments mixed in the hydrogel. The hydrogel includes a first collagen. The microfilament includes a second collagen. The diameter of the microfilament is ranging from 5 microns to 200 microns. The weight ratio of the microfilaments to the first collagen is ranging from 0.01:1 to 10:1.

The present invention provides compositions and methods for repair and reconstruction of defects and injuries to soft tissues. Some aspects of the invention provide tissue adhesives comprising a hybrid hydrogel by using a naturally derived polymer, gelatin and a synthetic polymer, polyethylene glycol, wherein the hydrogel is biocompatible, biodegradable, transparent, strongly adhesive to corneal tissue, and have a smooth surface and biomechanical properties similar to the cornea.