This invention provides compositions for controlled localized depositing of one or more drugs within a subject. More particularly, described herein are compositions comprising a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da) and b) a mucoadhesive in polymer. Alternatively, composition may comprise a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da), b) a water insoluble polymer and c) a mucoadhesive polymer. Furthermore, the composition may further comprise one or more drugs. Also provided are methods of manufacturing and administering the compositions described herein, which are used as biodegradable, injectable mucoadhesive low-viscosity pastes.

This invention provides compositions for controlled localized depositing of one or more drugs within a subject. More particularly, described herein are compositions comprising a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da) and b) a mucoadhesive in polymer. Alternatively, composition may comprise a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da), b) a water insoluble polymer and c) a mucoadhesive polymer. Furthermore, the composition may further comprise one or more drugs. Also provided are methods of manufacturing and administering the compositions described herein, which are used as biodegradable, injectable mucoadhesive low-viscosity pastes.

Provided is a flame-retardant resin composition containing a thermoplastic resin and a polysaccharide, wherein the polysaccharide includes an acidic polysaccharide composed of one or more selected from the group consisting of a polysaccharide having an acidic functional group, a derivative of the polysaccharide having an acidic functional group in which a site other than the acidic functional group is modified, and a salt thereof; and a total number of the acidic functional group and the salt thereof per monosaccharide unit in the acidic polysaccharide is in the range of 0.2 to 1.5.

The instant application relates to nanogels or compositions that hold multivalent metal ions until some level of nanogel degradation has occurred, then slowly release the multivalent metal ions for gelation with carboxylate containing polymers. Compositions comprising such nanogels, together with polymers that can be crosslinked with multivalent metal ions, allow the deployment of such mixtures in various applications, and greatly increased gelation times.

Disclosed is a method of fabricating an anode for a lithium-ion battery, including milling a mixture of nano-silicon, one or more carbonaceous materials and one or more solvents, wherein the mixture is retained as a wet slurry during milling. The mixture is carbonised to produce a silicon thinly coated with carbon (Si@C) material. Further milling occurs of a second mixture of the Si@C material, one or more graphite, one or more second carbonaceous materials and one or more second solvents, wherein the second mixture is retained as a second wet slurry during milling. The second mixture is carbonised to produce a Si@C/graphite/carbon material. The anode is formed from the Si@C/graphite/carbon material.

Disclosed is a method of fabricating an anode for a lithium-ion battery, including milling a mixture of nano-silicon, one or more carbonaceous materials and one or more solvents, wherein the mixture is retained as a wet slurry during milling. The mixture is carbonised to produce a silicon thinly coated with carbon (Si@C) material. Further milling occurs of a second mixture of the Si@C material, one or more graphite, one or more second carbonaceous materials and one or more second solvents, wherein the second mixture is retained as a second wet slurry during milling. The second mixture is carbonised to produce a Si@C/graphite/carbon material. The anode is formed from the Si@C/graphite/carbon material.

The present application belongs to a technical field of modifying natural polymer materials, provides a high-viscosity lithium carboxymethyl cellulose and preparation method therefor and application thereof. Raw materials are fed into a reactor, and the high-viscosity lithium carboxymethyl cellulose is prepared through an alkalization reaction, an etherification reaction, an acidification reaction and a substitution reaction. The prepared high-viscosity lithium carboxymethyl cellulose can be used for preparing a negative electrode plate of a lithium-ion battery. Compared with the existing lithium carboxymethyl cellulose, the high-viscosity lithium carboxymethyl cellulose provided by the present application can not only reduce an application amount in preparing a negative electrode plate of a lithium-ion battery so as to save a using cost, but also promote an electrochemical performance of the material in combination with a sodium lignin sulfonate.

A method is disclosed of in-situ retention and buffering of an amount of water in soil to support the growth of an agricultural crop. The method comprises the step of adding an effective amount of a hydrogel material as a water retention agent during planting of seed in the soil. The hydrogel material including an insoluble, cross-linked carboxymethyl cellulose. Once penetration of water into the soil is allowed after the planting of seed, a proportion of the water which penetrates the soil is absorbed by the hydrogel material and, over time, the absorbed water is released by diffusion into the soil to support the growth of the agricultural crop. Also disclosed is the hydrogel material which comprises said carboxymethyl cellulose which has been cross-linked with a cross-linking polymer from the group consisting of: an amine monomer; an amide monomer; and an amine-amide co-polymer.

Large molecular weight alginates which are covalently modified to store and release nitric oxide, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates may be tailored to release nitric oxide in a controlled manner and are useful for eradication of both planktonic and biofilm-based bacteria.

A method for consolidating a fibrous material of plant-based fibers, such as cellulose fibers and/or poly-lactic acid fibers, the method including: applying to the fibrous material an aqueous solution including a cellulose derivative, and/or a salt thereof, and an acid, the aqueous solution having a pH within the range of from 3 to 7, optionally within the range of from 3 to 6, optionally within the range of from 3 to 4.5; and drying the bonded fibrous material, optionally at 100° C. or higher. Also, a fibrous material formed by the method, an aqueous binder solution including a cellulose derivative, and/or a salt thereof, and an acid, and a nonwoven material including airlaid plant-based fibers being consolidated by a bio-based binder in the presence of a carboxylic acid, the bio-based binder being a cellulose derivative, and/or a salt thereof.