The present disclosure relates to a coating method of implant using parylene, for coating a surface of a dental implant, including a pretreating step of pretreating the implant; and a coating step of coating a surface of the pretreated implant with a coating material to form a polymer coating layer, wherein the coating material is provided as parylene.

According to the present disclosure, a parylene thin film may be uniformly coated on the surface of the dental implant, and according to such a thin film, the growth of anaerobic bacteria can be effectively inhibited in spaces where the fixture and the upper structure of the dental implant are joined to each other, and where the upper structure and the crown are joined to each other.

The present disclosure relates to a coating method of implant using parylene, for coating a surface of a dental implant, including a pretreating step of pretreating the implant; and a coating step of coating a surface of the pretreated implant with a coating material to form a polymer coating layer, wherein the coating material is provided as parylene.

According to the present disclosure, a parylene thin film may be uniformly coated on the surface of the dental implant, and according to such a thin film, the growth of anaerobic bacteria can be effectively inhibited in spaces where the fixture and the upper structure of the dental implant are joined to each other, and where the upper structure and the crown are joined to each other.

Medical devices such as stents, stent grafts, and balloon catheters include a coating layer applied over a modified exterior surface of the medical device. The modified exterior surface comprises an exterior surface of the medical device subjected to a surface modification that decreases a surface free energy of the exterior surface before application of the coating layer an exterior surface. The coating layer comprises a hydrophobic therapeutic agent and at least one additive. The modified exterior surface may affect the release kinetics of the drug from the device, the crystallinity of the drug layer, the surface morphology of the coating and particle shape, or the particle size of drug of a therapeutic layer in the coating layer. For example, the effects caused by the modified exterior surface may increase the retention time and amount of therapeutic agent in tissue.

Medical devices such as stents, stent grafts, and balloon catheters include a coating layer applied over a modified exterior surface of the medical device. The modified exterior surface comprises an exterior surface of the medical device subjected to a surface modification that decreases a surface free energy of the exterior surface before application of the coating layer an exterior surface. The coating layer comprises a hydrophobic therapeutic agent and at least one additive. The modified exterior surface may affect the release kinetics of the drug from the device, the crystallinity of the drug layer, the surface morphology of the coating and particle shape, or the particle size of drug of a therapeutic layer in the coating layer. For example, the effects caused by the modified exterior surface may increase the retention time and amount of therapeutic agent in tissue.

A biomimetic, polymeric composite biomaterial designed as a heart valve leaflet substitute that can be used for heart valve repair and/or to fabricate a new-generation of durable heart valve prosthesis.

A biomimetic, polymeric composite biomaterial designed as a heart valve leaflet substitute that can be used for heart valve repair and/or to fabricate a new-generation of durable heart valve prosthesis.

In an embodiment, a method of producing a radiopaque stent graft is provided. The method may include functionalizing a surface of a coating layer of a stent graft to produce a functionalized surface; disposing a tie layer over the functionalized exterior surface of the stent graft; disposing an adherent layer over the tie layer; etching a slot into the adherent layer; functionalizing the slot; and positioning a radiopaque marker in the slot to produce a filled slot and thereby produce the radiopaque stent graft.

In an embodiment, a method of producing a radiopaque stent graft is provided. The method may include functionalizing a surface of a coating layer of a stent graft to produce a functionalized surface; disposing a tie layer over the functionalized exterior surface of the stent graft; disposing an adherent layer over the tie layer; etching a slot into the adherent layer; functionalizing the slot; and positioning a radiopaque marker in the slot to produce a filled slot and thereby produce the radiopaque stent graft.

In an embodiment, a method of producing a radiopaque stent graft is provided. The method may include functionalizing a surface of a coating layer of a stent graft to produce a functionalized surface; disposing a tie layer over the functionalized exterior surface of the stent graft; disposing an adherent layer over the tie layer; etching a slot into the adherent layer; functionalizing the slot; and positioning a radiopaque marker in the slot to produce a filled slot and thereby produce the radiopaque stent graft.

A solvatochromic indicator for detecting the presence of a bacterial infection is disclosed. An indicator consisting of Beta vulgaris and further optionally comprising Curcuma longa, isopropyl alcohol, and any combination thereof, undergoes a detectable color change in the presence of an infection. Further provided are filaments treated with the solvatochromic indicator wherein the detectable color change of the indicator is based on the pH of the tissues with a bacterial infection.