This invention provides compositions for controlled localized depositing of one or more drugs within a subject. More particularly, described herein are compositions comprising a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da) and b) a mucoadhesive in polymer. Alternatively, composition may comprise a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da), b) a water insoluble polymer and c) a mucoadhesive polymer. Furthermore, the composition may further comprise one or more drugs. Also provided are methods of manufacturing and administering the compositions described herein, which are used as biodegradable, injectable mucoadhesive low-viscosity pastes.

Compositions include a plurality of polymer particulates comprising a matrix polymer and one or more types of nanoparticles selected from the group consisting of biopolymer nanoparticles, biomineral nanoparticles excluding biomineralized silica alone, and any combination thereof. Illustrative examples of such nanoparticles may include cellulose nanoparticles, hydroxyapatite nanoparticles, or any combination thereof associated with the matrix polymer. The polymer particulates may be prepared by melt emulsification. Methods include depositing such polymer particulates in a powder bed; and heating a portion of the powder bed to consolidate a portion of the polymer particulates into a consolidated part having a specified shape. The matrix polymer may be biodegradable and lose at least about 40% mass in six days in a phosphate buffer solution (0.2 M, pH 7.0) containing 0.2 mg/mL of lipase obtained from Pseudomonas cepacia (≥30 U/mg) and incubated at 37° C.

Compositions include a plurality of polymer particulates comprising a matrix polymer and one or more types of nanoparticles selected from the group consisting of biopolymer nanoparticles, biomineral nanoparticles excluding biomineralized silica alone, and any combination thereof. Illustrative examples of such nanoparticles may include cellulose nanoparticles, hydroxyapatite nanoparticles, or any combination thereof associated with the matrix polymer. The polymer particulates may be prepared by melt emulsification. Methods include depositing such polymer particulates in a powder bed; and heating a portion of the powder bed to consolidate a portion of the polymer particulates into a consolidated part having a specified shape. The matrix polymer may be biodegradable and lose at least about 40% mass in six days in a phosphate buffer solution (0.2 M, pH 7.0) containing 0.2 mg/mL of lipase obtained from Pseudomonas cepacia (≥30 U/mg) and incubated at 37° C.

Compositions include a plurality of polymer particulates comprising a matrix polymer and one or more types of nanoparticles selected from the group consisting of biopolymer nanoparticles, biomineral nanoparticles excluding biomineralized silica alone, and any combination thereof. Illustrative examples of such nanoparticles may include cellulose nanoparticles, hydroxyapatite nanoparticles, or any combination thereof associated with the matrix polymer. The polymer particulates may be prepared by melt emulsification. Methods include depositing such polymer particulates in a powder bed; and heating a portion of the powder bed to consolidate a portion of the polymer particulates into a consolidated part having a specified shape. The matrix polymer may be biodegradable and lose at least about 40% mass in six days in a phosphate buffer solution (0.2 M, pH 7.0) containing 0.2 mg/mL of lipase obtained from Pseudomonas cepacia (≥30 U/mg) and incubated at 37° C.

Provided is a flame-retardant resin composition containing a thermoplastic resin and a polysaccharide, wherein the polysaccharide includes an acidic polysaccharide composed of one or more selected from the group consisting of a polysaccharide having an acidic functional group, a derivative of the polysaccharide having an acidic functional group in which a site other than the acidic functional group is modified, and a salt thereof; and a total number of the acidic functional group and the salt thereof per monosaccharide unit in the acidic polysaccharide is in the range of 0.2 to 1.5.

Provided is a flame-retardant resin composition containing a thermoplastic resin and a polysaccharide, wherein the polysaccharide includes an acidic polysaccharide composed of one or more selected from the group consisting of a polysaccharide having an acidic functional group, a derivative of the polysaccharide having an acidic functional group in which a site other than the acidic functional group is modified, and a salt thereof; and a total number of the acidic functional group and the salt thereof per monosaccharide unit in the acidic polysaccharide is in the range of 0.2 to 1.5.

A moldable medical membrane is provided, which includes a compact layer and a porous layer. The compact layer is formed from a first material. The porous layer is disposed on the compact layer, and the porous layer is formed from a second material. The moldable medical membrane has a moldable temperature range. A melting point of the compact layer is within the moldable temperature range, and a melting point of the porous layer is higher than the moldable temperature range.

A moldable medical membrane is provided, which includes a compact layer and a porous layer. The compact layer is formed from a first material. The porous layer is disposed on the compact layer, and the porous layer is formed from a second material. The moldable medical membrane has a moldable temperature range. A melting point of the compact layer is within the moldable temperature range, and a melting point of the porous layer is higher than the moldable temperature range.

Provided are a nanofiber mesh bioelectrode including: a nanofiber mesh sheet in which nanofibers containing a biocompatible water-soluble polymer are entangled in a network form; and a conductive layer coated on the nanofiber mesh sheet and including a conductive material, and a method of producing the same. The nanofiber mesh bioelectrode according to the present invention does not cause discomfort when applied to a living body due to its excellent biocompatibility and excellent flexibility, and easily measures a biosignal or easily applies stimulation for a long period of time, as the nanofiber mesh bioelectrode is not easily detached.

Provided are a nanofiber mesh bioelectrode including: a nanofiber mesh sheet in which nanofibers containing a biocompatible water-soluble polymer are entangled in a network form; and a conductive layer coated on the nanofiber mesh sheet and including a conductive material, and a method of producing the same. The nanofiber mesh bioelectrode according to the present invention does not cause discomfort when applied to a living body due to its excellent biocompatibility and excellent flexibility, and easily measures a biosignal or easily applies stimulation for a long period of time, as the nanofiber mesh bioelectrode is not easily detached.