The present invention provides a composition for restoration of tissue including a biodegradable polymeric copolymer which is obtained by polymerizing a hydrophobic biodegradable polymer and a hydrophilic biodegradable polymer. The composition of the present invention has excellent tissue restoration effects because of high collagen production rate without occurrence of nodules even when injected directly into the dermis, unlike the conventional composition for restoration of tissue.

The present invention provides a composition for restoration of tissue including a biodegradable polymeric copolymer which is obtained by polymerizing a hydrophobic biodegradable polymer and a hydrophilic biodegradable polymer. The composition of the present invention has excellent tissue restoration effects because of high collagen production rate without occurrence of nodules even when injected directly into the dermis, unlike the conventional composition for restoration of tissue.

The present invention provides a composition for restoration of tissue including a biodegradable polymeric copolymer which is obtained by polymerizing a hydrophobic biodegradable polymer and a hydrophilic biodegradable polymer. The composition of the present invention has excellent tissue restoration effects because of high collagen production rate without occurrence of nodules even when injected directly into the dermis, unlike the conventional composition for restoration of tissue.

Polymeric composition comprising, with respect to the total composition: i) 30-95% by weight, preferably between 50-85% by weight with respect to the sum of components i)-vi), of at least one polyester comprising: a) a dicarboxylic component comprising, with respect to the total of the dicarboxylic component: a1) 30-70% by moles of units deriving from at least one aromatic dicarboxylic acid; a2) 70-30% by moles of units deriving from at least one saturated aliphatic dicarboxylic acid; a3) 0-5% by moles of units deriving from at least one unsaturated aliphatic dicarboxylic acid; b) a diol component comprising, with respect to the total diol component: b1) 95-100% by moles of units deriving from at least one saturated aliphatic diol; b2) 0-5% by moles of units deriving from at least one unsaturated aliphatic diol; ii) 0.1-50% by weight with respect to the sum of components i)-vi), of at least one polymer of natural origin; iii) 0.1-10% by weight with respect to the sum of components i)-vi) of at least one polyhydroxy alkanoate different from a lactic acid polyester referred to in point iv); iv) 0-3% by weight with respect to the sum of components i)-vi) of at least one lactic acid polyester; v) 0-1% by weight, preferably 0-0.5% by weight, with respect to the sum of the components i)-vi) of at least one cross-linking agent and/or a chain extender and/or hydrolytic stabilizer comprising at least one compound di- and/or polyfunctional containing isocyanate, peroxide, carbodiimide, isocyanurate, oxazoline, epoxide, anhydride, diviniether groups and mixtures of these; vi) 0-15% by weight, with respect to the sum of components i)-vi), of at least one inorganic filling agent.

Polymeric composition comprising, with respect to the total composition: i) 30-95% by weight, preferably between 50-85% by weight with respect to the sum of components i)-vi), of at least one polyester comprising: a) a dicarboxylic component comprising, with respect to the total of the dicarboxylic component: a1) 30-70% by moles of units deriving from at least one aromatic dicarboxylic acid; a2) 70-30% by moles of units deriving from at least one saturated aliphatic dicarboxylic acid; a3) 0-5% by moles of units deriving from at least one unsaturated aliphatic dicarboxylic acid; b) a diol component comprising, with respect to the total diol component: b1) 95-100% by moles of units deriving from at least one saturated aliphatic diol; b2) 0-5% by moles of units deriving from at least one unsaturated aliphatic diol; ii) 0.1-50% by weight with respect to the sum of components i)-vi), of at least one polymer of natural origin; iii) 0.1-10% by weight with respect to the sum of components i)-vi) of at least one polyhydroxy alkanoate different from a lactic acid polyester referred to in point iv); iv) 0-3% by weight with respect to the sum of components i)-vi) of at least one lactic acid polyester; v) 0-1% by weight, preferably 0-0.5% by weight, with respect to the sum of the components i)-vi) of at least one cross-linking agent and/or a chain extender and/or hydrolytic stabilizer comprising at least one compound di- and/or polyfunctional containing isocyanate, peroxide, carbodiimide, isocyanurate, oxazoline, epoxide, anhydride, diviniether groups and mixtures of these; vi) 0-15% by weight, with respect to the sum of components i)-vi), of at least one inorganic filling agent.

A polymer composition is disclosed which composition includes at least a first polymer and a second polymer. The first polymer is made up of at least 10 mole percent repeat units of (3-hydroxypropionate). The second polymer is made up of a poly(hydroxyalkanoate) which does not include repeat units of (3-hydroxypropionate). A method for making the first polymer is also disclosed.

A polymer composition is disclosed which composition includes at least a first polymer and a second polymer. The first polymer is made up of at least 10 mole percent repeat units of (3-hydroxypropionate). The second polymer is made up of a poly(hydroxyalkanoate) which does not include repeat units of (3-hydroxypropionate). A method for making the first polymer is also disclosed.

A poly(hydroxyalkanoate) composition having a bimodal molecular weight distribution. The composition includes of a first portion and a second portion of a poly(hydroxyalkanoate). The first portion has a first weight average molecular weight and the second portion has a second weight average molecular weight which is at least 50 percent less than the first weight average molecular weight. The poly(hydroxyalkanoate) is made up of at least 10 mole percent monomer repeat units of 3-hydroxypropionate. A method for making the composition is also disclosed.

A poly(hydroxyalkanoate) composition having a bimodal molecular weight distribution. The composition includes of a first portion and a second portion of a poly(hydroxyalkanoate). The first portion has a first weight average molecular weight and the second portion has a second weight average molecular weight which is at least 50 percent less than the first weight average molecular weight. The poly(hydroxyalkanoate) is made up of at least 10 mole percent monomer repeat units of 3-hydroxypropionate. A method for making the composition is also disclosed.

A poly(hydroxyalkanoate) composition having a bimodal molecular weight distribution. The composition includes of a first portion and a second portion of a poly(hydroxyalkanoate). The first portion has a first weight average molecular weight and the second portion has a second weight average molecular weight which is at least 50 percent less than the first weight average molecular weight. The poly(hydroxyalkanoate) is made up of at least 10 mole percent monomer repeat units of 3-hydroxypropionate. A method for making the composition is also disclosed.