Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

This current disclosure is directed to charge-transfer heptamethine dyes for NIR singlet oxygen generation, each such dye comprising a near-infrared (NIR) absorbing dye having heptamethine linkages orthogonally coupled to an optionally substituted cationic heteroaryl ring moiety as a charge-transfer partner and uses thereof.

The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.

A composition includes two or more near infrared absorbing compounds having an absorption maximum in a wavelength range of 650 to 1000 nm and having a solubility of 0.1 mass % or lower in water at 23° C., in which the two or more near infrared absorbing compounds include a first near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm, and a second near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm which is shorter than the absorption maximum of the first near infrared absorbing compound, and a difference between the absorption maximum of the first near infrared absorbing compound and the absorption maximum of the second near infrared absorbing compound is 1 to 150 nm.

Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

A fluorescent resin composition including a urethane resin which is a polymer having at least a polyol compound (A), a polyisocyanate compound (B) and a chain-extending compound (C) as structural units, and a fluorescent dye that emits fluorescence by undergoing irradiation with near infrared light within a wavelength region of 700 nm to 1300 nm, the polyol compound (A) being an aliphatic polycarbonate diol (A1). In addition, a molded object made of the above-described fluorescent resin composition, and also a medical device including the molded object. Examples of the medical device can include a wire for detecting the position of a lymph vessel that includes the molded object made of the fluorescent resin composition as a fluorescent marker.

Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.

A luminescent solar concentrator (LSC) device is provided. The LSC device has an active layer including a modified luminophore having a polymethine component including a plurality of methine groups (═CH—).sub.n, where n is an odd integer greater than 1. A hydrogen atom (H) of one of the plurality of methine groups is replaced by one of -AR.sub.1R.sub.2 or -DR.sub.3, where A is selected from nitrogen (N), phosphorus (P), arsenic (As) and antimony (Sb) and D is selected from oxygen (O), sulfur (S), selenium (Se), and tellurium (Te), R.sub.1 and R.sub.2 are independently selected from H, aliphatic groups, and aromatic groups bound to A through a carbon atom, or R.sub.1 and R.sub.2 together form an alicyclic ring containing A, and R.sub.3 is selected from H, aliphatic groups, aromatic groups, and alicyclic groups bound to D through a carbon atom.