Rapid prototyping and delivery of fluorescent medical devices using a 3D printer provided with a processed digital design and fluorescent filament feedstock. The fluorescent filament may comprise a polymer such as acrylonitrile butadiene styrene and between 10 and 100 ppm of a fluorophore such as indocyanine green embedded uniformly throughout the polymer. The filament may include about one percent by weight of a colorant. The 3D printer may be located at the site of use by an end user, such as a physician office, hospital, or operating room for printing of the fluorescent medical device on demand.

The present invention relates to compounds of formula I, wherein D is a detectable moiety, or salts thereof, which can be used as activity-based probes for neutrophil elastase, as well as to methods for detecting neutrophil elastase (NE) activity in a tissue sample lysate, and related diagnostic methods using compounds of formula I.

##STR00001##

The present invention relates to photopolymer comprising a photopolymerizable component and a photo initiator system. Further aspects of the present invention are a holographic media which comprises such a photopolymer, a display which comprises such a holographic media and the use of such a holographic media to make chip cards, security documents, bank notes and/or holographic optical elements especially for displays.

The present invention relates to novel methine dyes, methods for the preparation thereof and use thereof for dyeing plastics, especially polyamides, so as to obtain yellow colorings with improved light fastness and improved thermostability.

The present disclosure concerns the design, formulations, preparations and optical properties of compounds of Formulas (I) and (VI):

(charged dye.sup.m+).sub.x.Math.(counterion.sup.n−).sub.y.Math.(counterion receptor).sub.z  (I) and

(charged dye.sup.m−).sub.x.Math.(counterion.sup.n+)y.Math.(counterion receptor).sub.z  (VI).

The charged dye.sup.m+ is a cationic dye, counterion.sup.n− is an anion, and counterion receptor is a binding ligand for the counterion.sup.n−, wherein m, n, x and y are integers greater than or equal to 1, and products of x.Math.n and m.Math.y are identical for formula (I).

The charged dye.sup.m− is a anionic dye, counterion.sup.n+ is a cation, and counterion receptor is a binding ligand for the counterion.sup.n+, wherein m, n, x and y are integers greater than or equal to 1, and products of x.Math.n and m.Math.y are identical for formula (VI).

Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent spectral characteristics and exhibiting excellent storage stability. The probe for a biological specimen contains, as an active agent, at least one kind of compound represented by a general formula (I). ##STR00001##

The present invention relates to compounds of formula I, wherein D is a detectable moiety, or salts thereof, which can be used as activity-based probes for neutrophil elastase, as well as to methods for detecting neutrophil elastase (NE) activity in a tissue sample lysate, and related diagnostic methods using compounds of formula I.

##STR00001##

Provided are a fluorescent dye and a preparation process and use thereof. The fluorescent dye is able to emit a long wavelength, is sensitive and specific to viscosity, and is used for a wide range of purposes, such as viscosity testing, fluorescent labeling, quantification or detection of proteins, enzymes or nucleic acids. In addition, it can be used as a fluorescent-activated probe.

The present disclosure embodies compounds of Formula I, methods of use thereof, and kits thereof: ##STR00001## that are useful in connection with the detection of analytes of all types (e.g., biological molecules such as proteins, organic molecules, natural or synthetic molecules). The disclosure is particularly applicable to detection of proteins and nucleic acids using all types of membrane-based assays by techniques such as Western blotting, Dot blotting, Southern blotting, and Northern blotting.

A heat sensitive transfer sheet that achieves high optical density and high light resistance without generating scumming. The heat sensitive sheet has a base material and a coloring material layer formed on the base material, and the coloring material layer includes a compound represented by the following formula (1) and a particular dye compound: ##STR00001##
wherein
R.sup.11 and R.sup.13 each independently represent a hydrogen atom, an alkyl group, an aralkyl group, an unsubstituted aryl group or an aryl group having a substituent; and
R.sup.12 and R.sup.14 to R.sup.18 each independently represent a hydrogen atom or an alkyl group.