The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Rapid prototyping and delivery of fluorescent medical devices using a 3D printer provided with a processed digital design and fluorescent filament feedstock. The fluorescent filament may comprise a polymer such as acrylonitrile butadiene styrene and between 10 and 100 ppm of a fluorophore such as indocyanine green embedded uniformly throughout the polymer. The filament may include about one percent by weight of a colorant. The 3D printer may be located at the site of use by an end user, such as a physician office, hospital, or operating room for printing of the fluorescent medical device on demand.

Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

The present invention is a crystal of 3-(3-{[3-(cyclomaltoheptaos-21-O-yl)propyl]amino}-3-oxopropyl)-2-{(1E)-2-[(3E)-3-{(2E)-2-[3-(3-{[3-(cyclomaltoheptaos-21-O-yl)propyl]amino}-3-oxopropyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indo1-2-ylidene]ethylidene}-2-methoxycyclohex-1-en-1-yl]ethen-1-yl}-1,1-dimethyl-1H-benzo [e]indol-3-ium chloride.

Nonlinear optical chromophores are provided that have a short chain bridging group between donor and acceptor, which chromophores exhibit lowered λ.sub.max values and narrow absorption bands. Electro-optic films prepared from nonlinear optical chromophores provided have enhanced transparency to wavelengths outside of the narrow absorption bands, as well as low optic loss, high thermal stability, and high photostability.

The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.

A composition includes two or more near infrared absorbing compounds having an absorption maximum in a wavelength range of 650 to 1000 nm and having a solubility of 0.1 mass % or lower in water at 23° C., in which the two or more near infrared absorbing compounds include a first near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm, and a second near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm which is shorter than the absorption maximum of the first near infrared absorbing compound, and a difference between the absorption maximum of the first near infrared absorbing compound and the absorption maximum of the second near infrared absorbing compound is 1 to 150 nm.

A system and method for nanofabrication that can enable complex three-dimensional nanostructures comprising: setting up a gel scaffold; patterning the gel scaffold with a photosensitive patterning material, wherein light is used to pattern the photosensitive patterning material into the gel scaffold to create the shape of a desired construct (i.e., creating a latent pattern of the desired constructs shape); depositing build material onto the latent pattern, thereby creating the construct; and shrinking the construct to the desired size. The system and method leverage the photosensitivity of the photosensitive molecule and high precision of light positioning for the fabrication of a high-resolution construct. The system and method may enable the fabrication of nano-constructs of simple and complex material designs, wherein the constructs may implement multiple distinct build materials and gradients of build materials.

The present invention relates to: a labeling dye having excellent fluorescent intensity and photostability; and a kit.

Cyanine fluorophores including a nine-carbon polymethine bridge are disclosed. The cyanine fluorophores have absorbance and/or emission maxima in the near-infrared (NIR) and short-wave infrared (SWIR) wavelength ranges. Methods of making and using the cyanine fluorophores are also disclosed. The compounds are useful in fluorescence imaging, more particularly in cancer treatment. The compounds have generic formula (I): ##STR00001##