Disclosed is a mono-azo dichroic dye compound represented by the following Chemical Formula 1, a composition for polarizing plate, a polarizing plate, and an optical device.

##STR00001##

In Chemical Formula 1, Z represents any one selected from the group consisting of CN, COOR.sub.11, indanone and 1,3-dioxoindane, wherein R.sub.11 is any one selected from the group consisting of alkyl groups, aryl groups, and substituted or non-substituted heteroaryl groups. The mono-azo dichroic dye compound shows excellent dichroic properties, and has excellent heat resistance and photo-resistance, and thus may be used advantageously for a dye-based polarizing plate.

Disclosed is a mono-azo dichroic dye compound represented by the following Chemical Formula 1, a composition for polarizing plate, a polarizing plate, and an optical device.

##STR00001##

In Chemical Formula 1, R.sub.3 represents a substituted or non-substituted heterocyclic group having 1-20 carbon atoms. The mono-azo dichroic dye compound shows excellent dichroic properties, and has excellent heat resistance and photo-resistance, and thus may be used advantageously for a dye-based polarizing plate.

A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more than 4000 other human plasma proteins is disclosed. A contemplated compound corresponds in structure to Formula I, below, where the various substituents are defined within, and ##STR00001##
reacts chemoselectively with one or two of four Lys-15 -amino groups within the transthyretin tetramer. The crystal structure confirms the binding orientation of the compound substructure and the conjugating amide bond. A covalent transthyretin kinetic stabilizer exhibits superior amyloid inhibition potency, compared to a non-covalent counterpart, and inhibits cytotoxicity associated with amyloidogenesis.

A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more than 4000 other human plasma proteins is disclosed. A contemplated compound corresponds in structure to Formula I, below, where the various substituents are defined within, and

##STR00001##

reacts chemoselectively with one or two of four Lys-15 -amino groups within the transthyretin tetramer. The crystal structure confirms the binding orientation of the compound substructure and the conjugating amide bond. A covalent transthyretin kinetic stabilizer exhibits superior amyloid inhibition potency, compared to a non-covalent counterpart, and inhibits cytotoxicity associated with amyloidogenesis.