The present invention relates to a chemical compound comprising (i) a polycationic polymer, coupled to (ii) a dye. The present invention further relates to a method for visualizing a glycosamine-containing structure in a biological sample comprising a) contacting an inner lumen of said biological sample with a dye-conjugated polycationic polymer, preferably with the chemical compound according to the present invention; b) tissue-clearing said biological sample; and, thereby, c) visualizing an internal glycosamine-containing structure in said biological sample. The present invention also relates to a method for determining the number and/or size of glomeruli in a kidney or a sample thereof making use of the method for visualizing a glycosamine-containing structure; and also relates to kits and uses related to said chemical compounds and said methods.

The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.

The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.

Herein is described a light-emitting electrochemical cell comprising: a first electrode and a second electrode; a light-emitting layer disposed between the first and second electrodes and comprising a printed electrostatic ink comprising a thermoplastic resin having dispersed therein an electroluminescent material. Also described herein is a method of making an electrostatic ink, the method comprising: providing a carrier fluid (i) in which is dispersed a molten or a dissolved thermoplastic polymer resin and (ii) containing particles of an electroluminescent material suspended therein; effecting precipitation of the polymer resin from the carrier fluid onto the electroluminescent material to form particles comprising the electroluminescent material with a coating comprising the thermoplastic resin in solid form thereon. Also described herein is an electrostatic ink comprising: chargeable particles comprising an electroluminescent material having a coating of a thermoplastic resin thereon.

Conjugates comprising a drug, cell or biological molecule bound to a photoluminescent polymer nanoparticle, in particular a cross-linked polyfluorene nanoparticle, are described herein, as well as their methods of manufacture and their uses in biological imaging and sensing applications.

Conjugates comprising a drug, cell or biological molecule bound to a photoluminescent polymer nanoparticle, in particular a cross-linked polyfluorene nanoparticle, are described herein, as well as their methods of manufacture and their uses in biological imaging and sensing applications.

A photopolymerizable composition comprises at least a polymerizable resin, a photosensitizer, an annihilator, and a photoinitiator. The photosensitizer is formulated to absorb an excitation light signal received in a first range of wavelengths. The annihilator is formulated to emit a light signal in a second range of wavelengths different from the first. During the absorption of light by the photosensitizer in the first range of wavelengths, the annihilator emits a light signal in the second range, a photon energy of the emitted light signal being greater than a photon energy of the light signal received by the photosensitizer. The annihilator is also formulated to implement an energy transfer mechanism to excite the photoinitiator for polymerization of the resin. The excited photoinitiator is formulated to generate at least one polymerizable initiator to cause the polymerization reaction. Related methods, such as three-dimensional printing methods, and materials are also disclosed.

Chemiluminescent marking systems, and methods of making thereof. The chemiluminescent marking systems are configured to be moisture resistant and provide light over a broad range of temperature ranges. The chemiluminescent marking system may provide formulations or compositions which provide improvements over current chemiluminescent systems to one or more of the following attributes: 1) increased shelf-life, 2) easy use, 3) better performance in moist conditions, 4) performance over a broader range of temperatures, 5) the ability to reuse the same device over several days, and 6) more facile means of production.

Chemiluminescent marking systems, and methods of making thereof. The chemiluminescent marking systems are configured to be moisture resistant and provide light over a broad range of temperature ranges. The chemiluminescent marking system may provide formulations or compositions which provide improvements over current chemiluminescent systems to one or more of the following attributes: 1) increased shelf-life, 2) easy use, 3) better performance in moist conditions, 4) performance over a broader range of temperatures, 5) the ability to reuse the same device over several days, and 6) more facile means of production.

The present disclosure relates to a device including a reagent portion in which a chemiluminescent indicator and a chemiluminescent substrate for the indicator are disposed, and a base on which the reagent portion is formed. The chemiluminescent indicator and the chemiluminescent substrate are disposed independently from each other in the reagent portion in such a manner that the chemiluminescent indicator and the chemiluminescent substrate can react with each other when a sample is supplied to the reagent portion. The present disclosure also relates to a remote diagnosis system including an imaging terminal for detecting a luminescent signal generated when a reagent is supplied to the device and an information processing unit for processing luminescent signal data obtained by the imaging terminal. The imaging terminal and the information processing unit can bi-directionally communicate with each other via a network.