This invention relates to a soap bar composition which provides enhanced delivery of water soluble skin benefit agents such that the desired activity of the benefit agent is observed for a long time post the wash. This is achieved by absorbing/coating the benefit agent on to specific clays followed by further coating with a hydrophobic material selected from wax or petrolatum.

This invention relates to a soap bar composition which provides enhanced delivery of water soluble skin benefit agents such that the desired activity of the benefit agent is observed for a long time post the wash. This is achieved by absorbing/coating the benefit agent on to specific clays followed by further coating with a hydrophobic material selected from wax or petrolatum.

A two-stage method produces a liquid soap, having an alkaline pH and stable viscosity, so as to be efficacious in controlling pathogens and generating a thick lather which optimizes its cleansing and disinfecting effects. The method involves saponification of natural and/or synthetic oils/fats using of two lyes—potassium hydroxide and sodium hydroxide—which, when combined in roughly equal proportions, yield a lathery liquid soap without the need for synthetic surfactants or chemical thickeners. The method is also distinctive insofar as it first produces a solid soap concentrate, from which the liquid soap can be made simply by dissolving the solid soap concentrate in water.

A two-stage method produces a liquid soap, having an alkaline pH and stable viscosity, so as to be efficacious in controlling pathogens and generating a thick lather which optimizes its cleansing and disinfecting effects. The method involves saponification of natural and/or synthetic oils/fats using of two lyes—potassium hydroxide and sodium hydroxide—which, when combined in roughly equal proportions, yield a lathery liquid soap without the need for synthetic surfactants or chemical thickeners. The method is also distinctive insofar as it first produces a solid soap concentrate, from which the liquid soap can be made simply by dissolving the solid soap concentrate in water.

A two-stage method produces a liquid soap, having an alkaline pH and stable viscosity, so as to be efficacious in controlling pathogens and generating a thick lather which optimizes its cleansing and disinfecting effects. The method involves saponification of natural and/or synthetic oils/fats using of two lyes—potassium hydroxide and sodium hydroxide—which, when combined in roughly equal proportions, yield a lathery liquid soap without the need for synthetic surfactants or chemical thickeners. The method is also distinctive insofar as it first produces a solid soap concentrate, from which the liquid soap can be made simply by dissolving the solid soap concentrate in water.

A two-stage method produces a liquid soap, having an alkaline pH and stable viscosity, so as to be efficacious in controlling pathogens and generating a thick lather which optimizes its cleansing and disinfecting effects. The method involves saponification of natural and/or synthetic oils/fats using of two lyes—potassium hydroxide and sodium hydroxide—which, when combined in roughly equal proportions, yield a lathery liquid soap without the need for synthetic surfactants or chemical thickeners. The method is also distinctive insofar as it first produces a solid soap concentrate, from which the liquid soap can be made simply by dissolving the solid soap concentrate in water.

A solid cosmetic composition includes (i) sugar; (ii) a vegetable fiber, a fruit fiber or mixture thereof; and (iii) a soap. The solid cosmetic composition is prepared by dehydrating a liquid composition including (i) sugar in an amount of 33.75 to 47 wt. %; (ii) a vegetable fiber, a fruit fiber or mixture thereof, in an amount of 3.75 to 4.75 wt. %; (iii) a soap in an amount of 20 to 75 wt. %; and (iv) water in an amount of 11 to 15 wt. %. The amounts are based on the total combined amount of the sugar, the fiber, the soap and the water.

A solid cosmetic composition includes (i) sugar; (ii) a vegetable fiber, a fruit fiber or mixture thereof; and (iii) a soap. The solid cosmetic composition is prepared by dehydrating a liquid composition including (i) sugar in an amount of 33.75 to 47 wt. %; (ii) a vegetable fiber, a fruit fiber or mixture thereof, in an amount of 3.75 to 4.75 wt. %; (iii) a soap in an amount of 20 to 75 wt. %; and (iv) water in an amount of 11 to 15 wt. %. The amounts are based on the total combined amount of the sugar, the fiber, the soap and the water.

The present invention is about a pharmaceutical composition, an oral preparation, and an injection preparation containing a G protein-coupled Receptor19 (GPCR19) agonist, specifically sodium taurodeoxycholate (HY2191) and its derivative, as an active ingredient for preventing or treating allergic skin diseases. The present invention is also about an external preparation and a cosmetic composition containing said pharmaceutical composition for preventing and improving allergic skin diseases. The said pharmaceutical composition shows an excellent efficacy in treating and improving allergic dermatitis compared with the steroid ointments or immunosuppressive ointments currently used. The said pharmaceutical composition reduces the level of serum IgE, which is a major factor causing allergic dermatitis, increases TH1 cytokine alleviating allergic dermatitis and reduces TH2 cytokine that exacerbates allergic dermatitis. The said pharmaceutical composition also reduces infiltration of a mast cell, eosinophil, and neutrophil in dermis and ameliorates clinical symptoms such as erythema, hemorrhage, edema, excoriation, erosion, scaling and dryness. Thus, the said pharmaceutical composition can be used to prevent and treat allergic skin diseases.

The present invention is about a pharmaceutical composition, an oral preparation, and an injection preparation containing a G protein-coupled Receptor19 (GPCR19) agonist, specifically sodium taurodeoxycholate (HY2191) and its derivative, as an active ingredient for preventing or treating allergic skin diseases. The present invention is also about an external preparation and a cosmetic composition containing said pharmaceutical composition for preventing and improving allergic skin diseases. The said pharmaceutical composition shows an excellent efficacy in treating and improving allergic dermatitis compared with the steroid ointments or immunosuppressive ointments currently used. The said pharmaceutical composition reduces the level of serum IgE, which is a major factor causing allergic dermatitis, increases TH1 cytokine alleviating allergic dermatitis and reduces TH2 cytokine that exacerbates allergic dermatitis. The said pharmaceutical composition also reduces infiltration of a mast cell, eosinophil, and neutrophil in dermis and ameliorates clinical symptoms such as erythema, hemorrhage, edema, excoriation, erosion, scaling and dryness. Thus, the said pharmaceutical composition can be used to prevent and treat allergic skin diseases.