The present invention is a composting bioreactor system that continually receives biodegradable solid wastes, waste waters and exhaust gases, automatically recycles the biodegradable wastes into nutrients and heat energy, and automatically supplies the nutrients and heat into an integrated hydroponic or aquaponic system. This invention together with integrated food growing system may be installed onsite such as balconies, backyards and premises of restaurants and food factories etc. therefore may lead to zero mileage targets both for recycling wastes and for supplying foods. This invention integrates composting process and aquaponic technology together and may establish a closed-loop recirculation of both water and gases therefore upgrades aquaponics into compoponics. A compoponic system has both soil and soilless growing beds and mimics nature recirculating nutrients, carbon and energy among human being, animals, microorganisms and plants by way of photosynthesis, slow burning by cellular respiration and burning by combustion.

A configurable system for repeatably performing processes related to tissue growth in a controlled environment, possibly part of an industrial production line. The system can accommodate various sizes and shapes of culture vessels, and can maintain the cells at a desired temperature in the culture vessels, thus enabling a plug and play system that can produce consistent and repeatable results. The system includes gas management, fluid management, and control of multiple processes simultaneously, and can be automatically operably coupled with a variety of supporting technologies that can enable tissue-related processes. The system can communicate with supporting technologies upstream and downstream on a manufacturing line, enabling fully automated process control, centralized data historization, and centralized control.

The present invention relates to large-scale bioreactors having at least two impellers, large-scale bioreactor systems and methods for the large scale cultivation and propagation of mammalian cells using these bioreactors.

The present invention is a composting bioreactor system that continually receives biodegradable solid wastes, waste waters and exhaust gases, automatically recycles the biodegradable wastes into nutrients and heat energy, and automatically supplies the nutrients and heat into an integrated hydroponic or aquaponic system. This invention together with integrated food growing system may be installed onsite such as balconies, backyards and premises of restaurants and food factories etc. therefore may lead to zero mileage targets both for recycling wastes and for supplying foods. This invention integrates composting process and aquaponic technology together and may establish a closed-loop recirculation of both water and gases therefore upgrades aquaponics into compoponics. A compoponic system has both soil and soilless growing beds and mimics nature recirculating nutrients, carbon and energy among human being, animals, microorganisms and plants by way of photosynthesis, slow burning by cellular respiration and burning by combustion.

The present invention relates to large-scale bioreactors having at least two impellers, large-scale bioreactor systems and methods for the large scale cultivation and propagation of mammalian cells using these bioreactors.

The present invention relates to large-scale bioreactors having at least two impellers, large-scale bioreactor systems and methods for the large scale cultivation and propagation of mammalian cells using these bioreactors.

The present invention concerns a stirrer system for animal cell culture consisting of a combination of at least one radially-conveying stirrer element and at least one axially-conveying stirrer element, wherein at least three stirrer elements must be present and the uppermost stirrer element is an axially-conveying stirrer element. The stirrer elements are arranged at a certain distance above one another on a stirrer shaft. A particular embodiment is a multiple stirrer system consisting of two disk stirrers as radially-conveying stirrer elements and an inclined-blade stirrer as an axially-conveying stirrer element wherein the inclined-blade stirrer is arranged above the disk stirrer on the stirrer shaft. The stirrer system according to the invention achieves among others a gentler and better intermixing in the culture of shear-sensitive mammalian cells in cell cultures.

The present invention concerns a stirrer system for animal cell culture consisting of a combination of at least one radially-conveying stirrer element and at least one axially-conveying stirrer element, wherein at least three stirrer elements must be present and the uppermost stirrer element is an axially-conveying stirrer element. The stirrer elements are arranged at a certain distance above one another on a stirrer shaft. A particular embodiment is a multiple stirrer system consisting of two disk stirrers as radially-conveying stirrer elements and an inclined-blade stirrer as an axially-conveying stirrer element wherein the inclined-blade stirrer is arranged above the disk stirrer on the stirrer shaft. The stirrer system according to the invention achieves among others a gentler and better intermixing in the culture of shear-sensitive mammalian cells in cell cultures.

Biorcactor apparatus and methods for bioreactor processing are disclosed. A bioreactor apparatus has a vessel for containing liquid media and a head space gas and a Venturi pump assembly. The Venturi pump assembly has a media outlet conduit; a media inlet conduit; a pump device, configured to draw media from the vessel through the media outlet conduit and pass it to the media inlet conduit; and a foam collector member. The foam collector member has a mouth portion disposed within the vessel at a liquid media surface position; and a narrowed throat portion. The media inlet conduit is adapted to direct pumped media through the throat portion of the foam collector member, to generate therein a region of reduced pressure for aspirating surface foam into the mouth portion of the foam collector member.

The present invention relates to large-scale bioreactors having at least two impellers, large-scale bioreactor systems and methods for the large scale cultivation and propagation of mammalian cells using these bioreactors.