C12M41/06

Cell culture apparatus, imaging unit, and culture monitoring method

A cell culture apparatus includes a flow passage in which cell suspension containing at least one of cells or cell masses as granular bodies is to flow, and an imaging unit that is provided in a middle of the flow passage and continuously images the plurality of granular bodies contained in the cell suspension to acquire a plurality of images while the cell suspension flows in the flow passage.

SYSTEMS AND METHODS FOR ELECTRONICALLY AND OPTICALLY MONITORING BIOLOGICAL SAMPLES

A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.

TUBULAR BIOREACTOR
20230024082 · 2023-01-26 ·

A closed tubular bioreactor with clear corrugated or noncircular tubes having a constant cross-sectional area over their length, resulting in increased production.

DIGITAL ANTIMICROBIAL SUSCEPTIBILITY TESTING

Detecting single bacterial cells in a sample includes collecting, from a sample provided to an imaging apparatus, a multiplicity of images of the sample over a length of time; assessing a trajectory of each bacterial cell in the sample; and assessing, based on the trajectory of each bacterial cell in the sample, a number of bacterial cell divisions that occur in the sample during the length of time.

CONTACTLESS SELECTION DEVICE, LIGHT TRIGGERING STRUCTURE THEREOF, AND BIOLOGICAL PARTICLE SELECTION APPARATUS
20230226558 · 2023-07-20 ·

A contactless selection device, a light triggering structure thereof, and a biological particle selection apparatus are provided. The light triggering structure includes a first substrate, a first electrode layer formed on the first substrate, a photodiode layer formed on the first electrode layer, and an insulating layer that covers the photodiode layer. The photodiode layer has a thickness within a range from 1 .Math.m to 3 .Math.m, and includes a first doped layer, an I-type layer, and a second doped layer, which are sequentially stacked from the first electrode layer. The second doped layer includes a plurality of triggering pads spaced apart from each other. Each of the triggering pads has a width within a range from 3 .Math.m to 7 .Math.m, and a distance between any two of the triggering pads adjacent to each other is less than or equal to 2 .Math.m.

Cancer test device, cancer test method, and staining agent for use in cancer test

A cancer test device (1) is provided with: an application unit (40) for applying a staining agent (45), which can selectively stain a product of a cancer-relating gene in a living cell a chromatic color, onto a group of living cells; an imaging unit (10) for imaging the group of living cells having the staining agent (45) applied thereto; and a determination unit (52) for determining the level of malignancy of cancerization of the group of living cells on the basis of the state of the stained expression pattern of the cancer-relating gene in the group of living cells in an image obtained by the aforementioned imaging.

Measurement apparatus

A measurement apparatus according to an embodiment of the present technology includes a light source, a filling portion, and a detector. The light source emits illumination light. The filling portion includes a first surface portion and a second surface portion which are provided on an optical path of the illumination light and are opposite to each other, the filling portion enabling a cavity between the first and second surface portions to be filled with liquid including a cell. The detector detects an interference fringe of the illumination light passing through the cavity, the interference fringe being caused by the liquid including the cell.

Multi-sensor component for bioprocess control
11525710 · 2022-12-13 · ·

A multi-sensor component for the installation of at least two sensors at an individual port of a container for culturing biological material is provided. The multi-sensor component has a housing that can be introduced by a front housing segment into an uptake opening extending through the port of the container so that the front housing segment is facing the inside of the container. The multi-sensor component has a first sensor unit or a mount for a first sensor unit arranged on the front housing segment and has a second sensor unit or a mount for a second sensor unit arranged on the front housing segment.

METHOD AND DEVICE FOR THE PRODUCTION OF MICROALGAE BIOMASS
20220389357 · 2022-12-08 ·

The invention relates to the production of microalgae biomass. The microalgae contained in a suspension of water and microalgae are continuously phototrophically or mixotrophically cultivated in a cultivation module (1), which is passed multiple times by the suspension and has a gas part and a liquid part with a liquid supply (3), by supplying light from at least one artificial light source (5) and nutrients. According to the turbidity established by sensors, volume fractions of the suspension are repeatedly discharged from the cultivation module (1) for the harvest of microalgae and removed by means of a centrifuge (7). The cultivation of the microalgae occurs in an climate chamber forming the cultivation module (1), which is operated using water. Alongside a regulating of the temperature of the suspension, there also occurs a regulating of its pH value via the controlled addition of buffer ions and a regulating of the redox potential of the suspension and thereby also of its microbial contamination by controlling the light and nutrient supply, as well of a metered addition of oxygen. In addition, after the removal of microalgae, the remaining suspension is irradiated with UV light in order to kill unwanted microbial contamination before being returned into the cultivation module (1).

Device for Producing Metabolites
20220372416 · 2022-11-24 ·

A bioreactor for producing hydrogen gas and other metabolites. The bioreactor utilizes light, fermentation, and other metabolic processes for the production of metabolites, derived from various microorganisms contained within the bioreactor through respective metabolic pathways. The bioreactor comprises a main reactor chamber, a semipermeable membrane, a sleeve, a power supply, a substrate medium, a heating member, a plurality of tubing members, a collection reservoir, a pressure-sealed connecter member, and an agitator.