Patent classifications
C
C12
C12N
2710/00
C12N2710/00011
C12N2710/16011
C12N2710/16411
C12N2710/16451
C12N2710/16452
C12N2710/16452
Compositions and methods for generating reversion free attenuated and/or replication incompetent vaccine vectors
11149255
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2021-10-19
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Provided herein are methods for generating reversion free attenuated and/or replication incompetent vaccine vectors and their use in vaccine compositions and vaccination. In particular, the use of a codon shuffled helper gene is used to produce compositions comprising replication incompetent virus.
COMPOSITIONS AND METHODS FOR GENERATING REVERSION FREE ATTENUATED AND/OR REPLICATION INCOMPETENT VACCINE VECTORS
The disclosure provides methods for generating reversion free attenuated and/or replication incompetent vaccine vectors and their use in vaccine compositions and vaccination.