C12N2710/16452

Compositions and methods for generating reversion free attenuated and/or replication incompetent vaccine vectors

Provided herein are methods for generating reversion free attenuated and/or replication incompetent vaccine vectors and their use in vaccine compositions and vaccination. In particular, the use of a codon shuffled helper gene is used to produce compositions comprising replication incompetent virus.

COMPOSITIONS AND METHODS FOR GENERATING REVERSION FREE ATTENUATED AND/OR REPLICATION INCOMPETENT VACCINE VECTORS
20190211313 · 2019-07-11 ·

The disclosure provides methods for generating reversion free attenuated and/or replication incompetent vaccine vectors and their use in vaccine compositions and vaccination.