Patent classifications
C
C12
C12N
2740/00
C12N2740/00011
C12N2740/10011
C12N2740/11011
C12N2740/11051
C12N2740/11052
C12N2740/11052
GLYCOPROTEINS FOR PSEUDOTYPING RETROVIRAL VECTOR PARTICLES
The invention provides retroviral envelope glycoproteins in which the cytoplasmic C-terminal tail (CTT) from N-terminus to C-terminus comprises or consists of a T-domain and an R-domain, wherein the R-domain is truncated from its C-terminus, and hybrid glycoproteins and retroviral, especially alpharetroviral, lentiviral or gammaretroviral vector particles containing the glycoprotein. The glycoproteins target the SLC1A5 receptor for target cell entry.