Patent classifications
C
CHEMISTRY; METALLURGY
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C12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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C12N
MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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C12N2760/12211
Phlebovirus, e.g. Rift Valley fever virus
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C12N2760/12232
Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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C12N2760/12232

Rift valley fever virus replicon particles and use thereof
09687542 · 2017-06-27 · ·

Disclosed herein is a robust system for the reverse genetics generation of a Rift Valley fever (RVF) virus replicon particle (VRP.sub.RVF) vaccine candidate. VRP.sub.RVF can actively synthesize viral RNA and proteins, but lack structural glycoprotein genes, preventing spread within immunized individuals and reducing the risk of vaccine-induced pathogenicity. Is it disclosed herein that VRP.sub.RVF immunization is both safe and efficacious, resulting in a robust immune response that is protective against RVF virus challenge within 24 hours of immunization. Provided herein are VRP.sub.RVF, methods of producing VRP.sub.RVF, and method of using VRP.sub.RVF for immunization against RVF virus infection.